Is it true that gut microbiota is considered as panacea in cancer therapy?

Journal of Cellular Physiology
Amir Salek FarrokhiMajid Eslami

Abstract

Recent studies demonstrated that a combination of the gut microbiome has the vital effect on the efficacy of anticancer immune therapies. Regulatory effects of microbiota have been shown in different types of cancer therapies such as chemotherapy and immunotherapy. Immune-checkpoint-blocked therapies are the recent efficient cancer immunotherapy strategies. The target of immune-checkpoint blocking is cytotoxic T lymphocyte protein-4 (CTLA-4) or blockade of programmed death-1 (PD-1) protein and its ligand programmed death ligand 1 (PD-L1) that they have been considered as cancer immunotherapy in recent years. In the latest studies, it have been demonstrated that several gut bacteria such as Akkermansia muciniphila, Bifidobacterium spp., Faecalibacterium spp., and Bacteroides fragilis have the regulatory effects on PD-1, PD-L1, and CTLA-4 blocked anticancer therapy outcome.

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Citations

Jun 7, 2019·Journal of Cellular Physiology·Bahman YousefiMajid Eslami
Dec 7, 2019·Journal of Gastrointestinal Cancer·Amir Salek FarrokhiBahman Yousefi
Jul 21, 2020·Gut Microbes·Zhuxian ZhuZiqiang Zhang
Nov 19, 2019·Journal of Gastrointestinal Cancer·Majid EslamiBahman Yousefi
Oct 8, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·M EslamiB Yousefi
Aug 9, 2020·Allergologia et immunopathologia·M EslamiB Yousefi
Jun 15, 2021·New Microbes and New Infections·M KarbalaeiM Eslami

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