Is it useful to perform carbon monoxide diffusion capacity and respiratory muscle function tests in patients with multiple sclerosis without disability?

Respirology : Official Journal of the Asian Pacific Society of Respirology
Sonia Regina S CarvalhoRicardo M Dias

Abstract

Impairment of respiratory function has been described in end-stage multiple sclerosis (MS), as well as in patients with mild to severe disability. No data are available regarding the respiratory function of MS patients without disability. The objective of this study was to assess the pulmonary function, respiratory muscle strength and carbon monoxide diffusion capacity of the lungs (DL(CO)) in patients with relapsing-remitting multiple sclerosis (RRMS) without disability. Twenty-seven RRMS patients and 25 healthy control subjects were recruited. All subjects underwent clinical and neurological examination, and spirometry; lung volumes, DL(CO) and maximal respiratory pressures were measured. All subjects were rated on the Modified Fatigue Impact Scale and Fatigue Severity Scale scales. There were no significant differences in age, gender, height, weight or body mass index between the groups. The mean duration of illness in the MS group was 5.44 ± 3.74 years, and the mean Expanded Disability Status Scale was 0.62 ± 0.65. The mean values for total lung capacity, forced expiratory volume in 1 s (FEV(1)) and FEV(1) /FVC were normal in both groups. Fifteen RRMS patients exhibited a reduction in maximal expiratory pressure (MEP), but ...Continue Reading

References

Nov 1, 1986·The American Review of Respiratory Disease·R OlgiatiP E Di Prampero
Jan 1, 1994·The European Respiratory Journal·K FoglioN Ambrosino
Jan 1, 1997·The European Respiratory Journal·B BuyseL Kerkhofs
Feb 24, 2000·Acta Neurologica Scandinavica·M G GrassoS Paolucci
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Rohit Bakshi
Jun 3, 2005·Clinical Rehabilitation·F K MutluayS Saip
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Oct 19, 2006·Clinical Neurology and Neurosurgery·Ayse AltintasNurhayat Yildirim
Apr 6, 2007·Neurorehabilitation and Neural Repair·D KosS Ilsbroukx
Sep 19, 2007·Arquivos de neuro-psiquiatria·Karina PavanSergio Lianza
Apr 5, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Manuel Comabella, Samia J Khoury
May 11, 2011·The Journal of Clinical Investigation·Myat Lin OoTimothy Hla

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Citations

Aug 22, 2013·Journal of Anesthesia·Alexandros MakrisIosifina Karmaniolou
Apr 9, 2015·Disability and Rehabilitation·Andrew D RayNadine M Fisher
Jan 23, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Neil D EvesToby M Maher
Jan 5, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J LevyH Prigent

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