Is it Worth the Effort? Novel Insights into Obesity-Associated Alterations in Cost-Benefit Decision-Making

Frontiers in Behavioral Neuroscience
David MatharJane Neumann

Abstract

Cost-benefit decision-making entails the process of evaluating potential actions according to the trade-off between the expected reward (benefit) and the anticipated effort (costs). Recent research revealed that dopaminergic transmission within the fronto-striatal circuitry strongly modulates cost-benefit decision-making. Alterations within the dopaminergic fronto-striatal system have been associated with obesity, but little is known about cost-benefit decision-making differences in obese compared with lean individuals. With a newly developed experimental task we investigate obesity-associated alterations in cost-benefit decision-making, utilizing physical effort by handgrip-force exertion and both food and non-food rewards. We relate our behavioral findings to alterations in local gray matter volume assessed by structural MRI. Obese compared with lean subjects were less willing to engage in physical effort in particular for high-caloric sweet snack food. Further, self-reported body dissatisfaction negatively correlated with the willingness to invest effort for sweet snacks in obese men. On a structural level, obesity was associated with reductions in gray matter volume in bilateral prefrontal cortex. Nucleus accumbens volume p...Continue Reading

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Citations

Feb 18, 2017·International Journal of Environmental Research and Public Health·Binwu ShengLu Shi
Dec 12, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Martin J HerrmannBodo Warrings
Jul 20, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Isabel García-GarcíaAlain Dagher
Nov 23, 2017·Frontiers in Neuroscience·Lucas KastnerJane Neumann
Jul 31, 2021·Journal of Obesity·Erick Gómez-ApoJuan Silva-Pereyra

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