Is Italian population protected from Poliovirus? Results of a seroprevalence survey in Florence, Italy

Human Vaccines & Immunotherapeutics
Giovanni M GiammancoAntonino Nastasi

Abstract

Periodical assessments of population susceptibility to polioviruses (PV) is essential for evaluating population protection and planning appropriate vaccination strategies. The aim of the current work was to assess serological protective titers against all three polioviruses in the general population of Florence. A convenience sample of 328 sera, collected in 2009 in Florence (Central Italy) was analyzed. Samples were considered protective if neutralizing antibodies were detected at dilutions ≥1:8, according to the WHO protocols. The immune coverage was 75.3%, 69.2% and 46% for PV1, PV2 and PV3, respectively. The protective titers of neutralizing antibodies were generally higher in children up to 14 years of age, with 74.4% (PV1), 75.6% (PV2) and 56.7% (PV3) of seroprevalence. From the age of 11 years, most of the study subjects were seronegative for PV3. In a polio-free country with strong migration pressures, such as Italy, our results bring clear support to the recent recommendation of Italian health authorities to introduce a fifth dose of IPV vaccine in adolescence all over the country.

References

Mar 1, 1987·European Journal of Epidemiology·F NovelloP Pasquini
Jul 28, 1969·JAMA : the Journal of the American Medical Association·A Giovanardi
May 31, 1995·Annals of the New York Academy of Sciences·R W SutterS C Hadler
Nov 10, 2007·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M Pires de MirandaH Rebelo de Andrade
Jun 25, 2010·The New England Journal of Medicine·John F Modlin
Jan 28, 2012·BMC Infectious Diseases·Claudia ReinheimerHans W Doerr
Jun 13, 2012·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M HaverkateUNKNOWN VENICE project gatekeepers and contact points
Jun 29, 2012·Clinical and Vaccine Immunology : CVI·Vincenzo BaldoAndrea Trevisan
Feb 5, 2014·Lancet·R Bruce Aylward, Ala Alwan
Mar 1, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·N A van der MaasF R van der Klis
Mar 1, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Y ManorE Mendelson
Apr 22, 2015·Human Vaccines & Immunotherapeutics·Dre NijstenP L Lopalco
Sep 9, 2016·MMWR. Morbidity and Mortality Weekly Report·Lee M HamptonUNKNOWN Immunization Systems Management Group of the Global Polio Eradication Initiative

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Citations

Sep 2, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert Root-Bernstein
Jan 23, 2021·Biomedicines·Claudia FerlitoRaffaele D'Amelio

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