PMID: 26772049Jan 17, 2016Paper

Is Kauppila method able to detect the progression of vascular calcification and predict cardiovascular events in patients undergoing hemodialysis?

Clinical Nephrology
Francieli C Delatim VanniniPasqual Barretti

Abstract

Cardiovascular disease (CVD) is the main cause of death in hemodialysis (HD) patients. Vascular calcification (VC) is common in these patients. The main objective of this study was to evaluate if a semiquantitative radiographic method is able to detect VC progression in a prospective cohort of patients and predict the risk of cardiovascular events. Secondarily, we intend to identify predictors of the presence and progression of VC. 49 patients undergoing HD for ≥ 90 days were included. At the beginning and after 12 months, the VC score (VCS) was determined by the Kauppila method, and clinical, nutritional, and laboratory markers were measured. The rates of fatal and nonfatal cardiovascular events were analyzed from months 13 to 24. Of 49 patients, 55.1% were male, 46.9% diabetic, and the mean age was 59.5 ± 14.4 years. At the beginning of the follow-up, 65.3% of the patients exhibited VC with a median VCS of 4 points. The intracellular water was negatively associated with VC and its intensity. The presence of VC was the only independent predictor of VC progression. Among patients with VC, 17 showed rapid progression, and 15 showed slow progression. The VCS was independently associated with rapid progression, while ΔCS (final VC...Continue Reading

Citations

May 27, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yingzi HuangHongqi Ren

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