PMID: 59021Jun 26, 1976

Is lactase the receptor and uncoating enzyme for infantile enteritis (rota) viruses?

Lancet
I H HolmesG L Barnes

Abstract

Rotaviruses are now regarded as important causes of diarrhoea in man, cattle, pigs, mice, and possibly other animals. Characteristically, disease occurs in newborn and young animals, and infection seems limited to the differentiated gut epithelial cells. The major surface polypeptide of the calf scours rotavirus is glycosylated, and highly purified beta-galactosidase (lactase) interacts with the virus in vitro causing removal of the outer shell of the capsid (uncoating). It is suggested that lactase present in the brush border of the intestinal epithelial cell performs a similar function in vivo by acting as a combined receptor and uncoating enzyme for the rotavirus. This hypothesis is consistent with the observations that rotaviruses seem to infect only gut epithelial cells, and that infant animals, whose lactase concentrations are generally higher than those of adult animals, seem more susceptible to rotavirus infections. Implications of the hypothesis include possible new approaches to laboratory cultivation of rotaviruses, which should be more successful in cells selected for surface lactase activity, and the suggestion that the epidemiology of human rotavirus infections may be influenced by the fact that different ethnic g...Continue Reading

Citations

Jan 1, 1977·Archives of Virology·D R SnodgrassE W Gray
Jan 1, 1978·Archives of Virology·T H Flewett, G N Woode
Mar 13, 1979·Medical Microbiology and Immunology·L Brade, W A Schmidt
Sep 1, 1983·Indian Journal of Pediatrics·M WeymanF LIFSHITZ
Nov 1, 1984·The Canadian Nurse·J Wilson, G Riedel
Apr 1, 1990·Journal of Virological Methods·P M Aha, M I Sabara
Feb 11, 1978·Lancet·B D SchoubR M Robins-Browne
May 1, 1978·Archives of Disease in Childhood·J A Walker-Smith
Jan 1, 1979·Journal of Clinical Pathology·C R Madeley
Jan 1, 1985·Pediatric Annals·A G Angelides, M Davidson
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·K Villako, H Maaroos
Nov 1, 1984·Indian Journal of Pediatrics·M G WaghR K Shetty

Related Concepts

Acute Disease
Bos indicus
Infantile Diarrhea
Epithelial Cells
Mesothelium
Galactosidase
Intestines, Small
Mycoreovirus
Reoviridae Infections

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