Is laparoscopic surgery really effective for the treatment of colon and rectal cancer in very elderly over 80 years old? A prospective multicentric case-control assessment

Surgical Endoscopy
Francesco RoscioIldo Scandroglio

Abstract

To evaluate the effectiveness of laparoscopic surgery (LCS) for colon and rectal cancer in the very elderly over 80 years old. We performed a prospective multicentric analysis comparing patients over 80 years (Group A) and patients between 60 and 69 years (Group B) undergoing LCS for cancer from January 2008 to December 2013. Colon and rectal cancers were analyzed separately. Comorbidity and complications were classified using the Charlson comorbidity index (CCI) and the Clavien-Dindo system, respectively. Oncological parameters included tumor-free margins, number of lymph nodes harvested and circumferential resection margin. Group A included 96 and 33 patients, and Group B 220 and 82 for colon and rectal cancers, respectively. Groups were similar except for ASA score and CCI, as expected. There was no significant difference in operative time [colon; rectum] (180[IQR 150-200] vs 180[150-210] min; NS-180[160-210] vs 180[165-240] min; NS), estimated blood loss (50[25-75] vs 50[25-120] mL; NS-50[0-150] vs 50[25-108.7] mL; NS) and conversion rate (2.1 vs 2.7 %; NS-3.0 vs 2.4 %; NS). Timing of first stool (3[2-3.25] vs 3[2-5] dd; NS-3[2-4] vs 3[2-5] dd; NS), length of stay (7[6-8] vs 7[6-8] dd; NS-8[8-9] vs 8[7-9] dd; NS) and readmi...Continue Reading

References

Aug 26, 1998·Archives of Surgery·R J HealdJ K MacFarlane
May 1, 1999·Diseases of the Colon and Rectum·O SchwandnerH P Bruch
Jul 27, 1999·The British Journal of Surgery·B T StewartJ W Lumley
Mar 25, 2000·Diseases of the Colon and Rectum·L StocchiD M Ilstrup
Feb 23, 2002·The American Journal of Surgical Pathology·Iris D NagtegaalUNKNOWN Cooperative Clinical Investigators
Dec 24, 2002·Journal of the American College of Surgeons·Wai Lun LawPeter Hiu Ming Tung
Mar 4, 2003·Archives of Surgery·Anthony J SenagoreConor P Delaney
Apr 24, 2003·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Seiichiro YamamotoMasaki Kitajima
May 14, 2004·The New England Journal of Medicine·UNKNOWN Clinical Outcomes of Surgical Therapy Study GroupDavid Ota
Oct 1, 2004·Surgical Endoscopy·R VeldkampUNKNOWN European Association of Endoscopic Surgery (EAES)
Jul 5, 2005·The Lancet Oncology·Ruben VeldkampUNKNOWN COlon cancer Laparoscopic or Open Resection Study Group (COLOR)
Aug 9, 2005·Diseases of the Colon and Rectum·Andrea VignaliCarlo Staudacher
Jun 29, 2006·Aging Clinical and Experimental Research·Bo FengHong-Wei Li
Sep 26, 2007·Annals of Surgery·James FleshmanUNKNOWN Clinical Outcomes of Surgical Therapy Study Group
Jan 29, 2008·Journal of the American College of Surgeons·Julien ChautardYves Panis
Jul 8, 2010·American Journal of Surgery·Kok-Yang TanHisanaga Horie
Nov 26, 2010·Annals of Surgery·Daniel LeonardUNKNOWN PROCARE, a multidisciplinary Belgian Project on Cancer of the Rectum
Oct 12, 2011·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Francesco RoscioIldo Scandroglio
Nov 23, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Cynthia RobitailleHude Quan
May 30, 2012·Journal of the American College of Surgeons·Hossein MasoomiMichael J Stamos
Jul 24, 2012·Surgical Endoscopy·Wong-Hoi SheWai-Lun Law
Dec 15, 2012·Surgical Endoscopy·Marc ZereyUNKNOWN Members of the SAGES Guidelines Committee
Feb 12, 2013·The Lancet Oncology·Martijn Hgm van der PasUNKNOWN COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group
Apr 16, 2013·Annals of Coloproctology·Duck Hyoun JeongNam Kyu Kim
Jul 24, 2013·Surgical Endoscopy·Deborah S KellerConor P Delaney
Oct 15, 2013·Surgery Today·Yoshihiro MiyasakaAkira Miyoshi
Dec 5, 2013·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Tomoya HatakeyamaEigo Otsuji
Feb 4, 2014·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Takatoshi NakamuraMasahiko Watanabe
Apr 9, 2014·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Toshiki MukaiToshiharu Yamaguchi
Apr 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D JegouUNKNOWN PROCARE
Jul 16, 2014·International Journal of Colorectal Disease·M E HamakerA Pronk
Oct 22, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A H W SchiphorstM E Hamaker
Jan 20, 2015·International Journal of Colorectal Disease·Giulia DiamantiniFabio Procacciante

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Citations

Jul 14, 2017·Asian Journal of Endoscopic Surgery·Yugo NagaiTakahiko Tatsumi
Mar 22, 2018·Khirurgiia·Z B KhalilovF S Kurbanov
Jul 10, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S NiemeläinenM Hyöty
Dec 7, 2016·World Journal of Gastroenterology : WJG·Catalina MosqueraTimothy L Fitzgerald
Jun 5, 2018·Annals of Gastroenterological Surgery·Takeru MatsudaYoshihiro Kakeji
May 18, 2017·Khirurgiia·A Yu Kalinichenko, Z B Khalilov
Jul 27, 2017·Khirurgiia·A Yu KalinichenkoF S Kurbanov
Apr 22, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Meike J van HartenTarik Sammour

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