Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?

Oxidative Medicine and Cellular Longevity
Martha Lucinda Contreras-Zentella, R Hernández-Muñoz

Abstract

Hepatic diseases are a major concern worldwide. Increased specific plasma enzyme activities are considered diagnostic features for liver diseases, since enzymes are released into the blood compartment following the deterioration of the organ. Release of liver mitochondrial enzymes is considered strong evidence for hepatic necrosis, which is associated with an increased production of ROS, often leading to greater hepatic lipid peroxidation. Lipotoxic mediators and intracellular signals activated Kupffer cells, which provides evidence strongly suggesting the participation of oxidant stress in acute liver damage, inducing the progression of liver injury to chronic liver damage. Elevated transaminase activities are considered as an index marker of hepatotoxicity, linked to oxidant stress. However, a drastic increase of serum activities of liver enzyme markers ought not necessarily to reflect liver cell death. In fact, increased serum levels of cytoplasmic enzymes have readily been observed after partial hepatectomy (PH) in the regenerating liver of rats. In this regard, we are now showing that in vitro modifications of the oxidant status affect differentially the release of liver enzymes, indicating that this release is a strictly ...Continue Reading

References

Dec 10, 1977·British Medical Journal·L Van Waes, C S Lieber
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H Rubin, T Koide
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H G PeltenburgE Schmidt
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B NalpasP Berthelot
Mar 18, 1967·Nature·E Schmidt, F W Schmidt
Jan 1, 1968·Scandinavian Journal of Gastroenterology·S BengmarkR Olsson
Jan 1, 1969·Annals of Surgery·K F AronsenB Pihl
Jan 1, 1969·Annals of Surgery·O AlmersjöR Olsson
Jan 1, 1980·Annals of the New York Academy of Sciences·J F WhitfieldS H Swierenga
Oct 1, 1984·Cell Biochemistry and Function·W M FrederiksG M Fronik
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
May 1, 1997·Journal of Gastroenterology and Hepatology·J LudwigK D Lindor
Nov 5, 1999·Digestive Diseases and Sciences·J A Morales-GonzálezR Hernández-Muñoz
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ShimomuraJ L Goldstein
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rolando Hernández-MuñozMyrna A R Dent
Jul 5, 2003·BMJ : British Medical Journal·Giuseppe TraversaMauro Venegoni
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian Reuben
Aug 28, 2004·Clinics in Liver Disease·Joel E Lavine, Jeffrey B Schwimmer
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michal Carmiel-HaggaiNatalia Nieto
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Nov 22, 2005·Drugs·Jesús Medina, Ricardo Moreno-Otero
Jan 13, 2006·Gastroenterology·Christopher Paul Day
Aug 23, 2006·The Proceedings of the Nutrition Society·Emanuele Albano
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mirianas ChachisvilisJohn A Frangos
Feb 13, 2007·Biochemical and Biophysical Research Communications·Manolis Y PahakisJohn M Tarbell
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles R White, John A Frangos
Aug 29, 2007·Clinics in Liver Disease·Guruprasad P Aithal, Christopher P Day
Sep 15, 2007·World Journal of Gastroenterology : WJG·Terrence M Donohue
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nancy AdamekMichael A Geeves
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Craig LammertNaga Chalasani
Aug 30, 2008·European Journal of Endocrinology·Lovisa E JohanssonMartin Ridderstråle
Feb 28, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Scott A ReismanCurtis D Klaassen
Apr 7, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Suresh R NaikSnehal R Patil

❮ Previous
Next ❯

Citations

May 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen-Ping JiangGuan-Jhong Huang
Dec 18, 2019·Rapid Communications in Mass Spectrometry : RCM·Matheus Coutinho GazollaNorberto Peporine Lopes
Feb 29, 2020·Future Medicinal Chemistry·Tao JiangWei Wang
Mar 10, 2017·World Journal of Gastroenterology : WJG·Taerim KimWon Young Kim
Mar 25, 2017·Oxidative Medicine and Cellular Longevity·Julieta A Díaz-Juárez, Rolando Hernández-Muñoz
Aug 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Melissa G KaltenbachDavid S Goldberg
Jun 4, 2020·Environmental Science and Pollution Research International·Shirin MoradkhaniAmir Nili-Ahmadabadi
Oct 28, 2016·Journal of Translational Medicine·Lourdes Sánchez-SevillaRolando Hernández-Muñoz
May 10, 2017·Oxidative Medicine and Cellular Longevity·Armando Butanda-OchoaRolando Hernández-Muñoz
Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuYuan-Shiun Chang
Apr 23, 2020·International Journal of Environmental Research and Public Health·Jin Hee Kim, Yun-Chul Hong
May 18, 2020·International Journal of Environmental Research and Public Health·Zaida ZainalHuzwah Khaza'ai
Nov 6, 2018·Journal of Toxicologic Pathology·Tomoyuki SaitoTakeshi Ohta
Sep 22, 2020·Journal of Toxicology·Anna Virginia Adriana PirozziMariateresa Giuliano
Nov 22, 2018·Archives of Endocrinology and Metabolism·Bruna Karoline Lima PiazeraMário Vaisman
Jan 7, 2021·Pharmaceutical Biology·Ernawati SinagaVivitri Dewi Prasasty
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hamza MechchateDalila Bousta
Mar 21, 2021·Tropical Medicine and Health·Kantarakorn KaewdanaChuchard Punsawad
Apr 14, 2021·Environmental Science and Pollution Research International·Heba N Gad El-HakHowayda E Khaled
May 1, 2021·Animals : an Open Access Journal From MDPI·Mousa ZarrinLorenzo E Hernández-Castellano
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammed EsmailMohammed Abdel-Gabbar
Jul 30, 2021·Environmental Science and Pollution Research International·Nahed Abdel-AzizMarwa G A Hegazy
Aug 12, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·I LiaqatN Arshad
Aug 18, 2021·PloS One·Martins EkorPatrick Kafui Akakpo
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·B AhmadA A K Khalil
Dec 12, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Muhammad NaeemTill Ittermann

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
MDA

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Julieta Díaz-Juárez, R Hernández-Muñoz
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
L J Roberts, J D Morrow
© 2022 Meta ULC. All rights reserved