Is low-dose intratympanic gentamicin an effective treatment for Ménière's disease: the Birmingham experience

The Journal of Laryngology and Otology
G J WatsonR M Irving

Abstract

Since the development of intratympanic aminoglycoside in the 1950s, otologists have been able to chemically ablate the vestibule. We present the results of using low-dose intratympanic gentamicin to treat Ménière's disease. A retrospective review was performed of all patients who underwent low-dose intratympanic gentamicin therapy over seven years. Data on gender, age, number of procedures, pure tone audiometry and symptom control were analysed. In all, 38 patients underwent low-dose intratympanic gentamicin therapy. These comprised 25 females and 13 males, with an average age of 58.4 years. Hearing was preserved in 87.5 per cent of patients, with no significant difference before and after treatment (p = 0.744). In all, 85.7 per cent of patients had complete or substantial symptom control (classes A and B, respectively). Low-dose intratympanic gentamicin therapy was effective in controlling the symptoms of Ménière's disease patients, while preserving hearing.

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Citations

Feb 16, 2016·The Journal of Laryngology and Otology·Robin YoungsJonathan Fishman
Mar 16, 2017·Auris, Nasus, Larynx·Béla Büki, Heinz Jünger
Oct 9, 2015·The Journal of Laryngology and Otology·Robin Youngs, Edward Fisher
Jul 17, 2019·The Journal of Laryngology and Otology·N AmiraraghiG Kontorinis
Mar 17, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Erika Celis-AguilarLeticia Martínez-Román
Nov 18, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Charn GillRichard Irving

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