Is low pre-transplant parathyroid hormone a risk marker for cardiovascular disease in long-term follow-up of renal transplant recipients?

Clinical and Experimental Nephrology
Elin IsakssonGunnar Sterner

Abstract

Secondary hyperparathyroidism and altered levels of parathyroid hormone (PTH) are associated with vascular events in chronic kidney disease. After renal transplantation, this association is not clear. Pre-transplant parathyroidectomy (PTX) is common, but post-transplant data are scarce. We aimed to study the effect of PTH at the time of transplantation on risk of post-transplant vascular events in renal transplant recipients with and without pre-transplant PTX. 258 patients from two Swedish transplant units were followed for 6 years. Separate analyses were made for patients with or without pre-transplant PTX. Patients with no pre-transplant PTX were stratified by quartiles of PTH at time of transplantation and patients with pre-transplant PTX were stratified by above and below median levels of PTH at time of transplantation. Hazard ratios for vascular events, mortality, and graft failure were calculated in adjusted Cox regression models. In patients with no pre-transplant PTX, the lowest quartile of PTH at transplantation had a higher risk of cardiovascular events compared to quartile 3 with an adjusted hazard ratio (95% CI) of 2.63 (1.04-6.67). In patients with pre-transplant PTX, the group below median of PTH had a higher ris...Continue Reading

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Citations

May 16, 2019·World Journal of Surgery·Kerstin M IvarssonMartin Almquist
Mar 19, 2019·Transplantation Proceedings·V Garcia-MontemayorP Aljama

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Methods Mentioned

BETA
biopsies

Software Mentioned

Immulite
SPSS

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