Is MAGE-1 expression in metastatic malignant melanomas really helpful?

The American Journal of Surgical Pathology
Nupoor A GajjarScott W Binder

Abstract

Melanoma antigen-encoding gene (MAGE-1) has been introduced as a sensitive immunohistochemical marker to aid in the diagnosis of malignant melanomas, in particular, those that are HMB-45 negative. Our goal was to determine the consistency of positive staining in melanomas on the basis of the usefulness of MAGE-1 in comparison with tyrosinase and MART-1. We studied 56 malignant melanomas using immunohistochemical markers to MAGE-1, tyrosinase, MART-1, HMB-45, and S-100. Six of 17 HMB-45-negative cases were strongly positive for MAGE-1 (35%), while 9 of 39 HMB-45-positive cases were positive for MAGE-1 (23%), overall, 27% positivity (n = 56). Tyrosinase and MART-1 were both strongly positive in 42 of 56 cases (75%). Fifty-two of 56 cases were strongly positive for S-100 (93%). We found MAGE-1 to be less sensitive than described in other studies, and overall, not very helpful, especially as a predictor of aggressive behavior. Although MAGE-1 expression has been considered as a target for immunomodulation therapy, our findings do not indicate consistent expression of this epitope in a majority of melanomas. S-100 protein, tyrosinase, and MART-1 immunomarkers were more frequently positive in our melanoma cases and appear to constitu...Continue Reading

References

Feb 20, 1995·International Journal of Cancer. Journal International Du Cancer·J J PatardD Chopin
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·M StatutoM Presta
Oct 21, 1996·International Journal of Cancer. Journal International Du Cancer·M V CorriasV Pistoia
Oct 1, 1996·Virchows Archiv : an International Journal of Pathology·F GudatG Spagnoli
Mar 1, 1997·Genomics·E De PlaenT Boon
Jan 1, 1997·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M ZuberM Heberer
Aug 17, 1999·Cancer Treatment Reviews·A M Gillespie, R E Coleman
Jun 1, 1997·The Australasian Journal of Dermatology·J CebonR DeBoer
Mar 21, 2001·Vaccine·J TartagliaP Moingeon
Jan 5, 2002·The American Journal of Surgical Pathology·Xiaowei XuPaul J Zhang

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Citations

Nov 29, 2007·Journal of Clinical Pathology·Andrew H S Lee
Jun 15, 2005·Clinical and Experimental Dermatology·E Calonje
Jan 8, 2019·Melanoma Research·Darryl TioMarcel W Bekkenk
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·F Stephen Hodi
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine BarrowJonathan Cebon

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