Is magnesium sulfate effective for pain in chronic postherpetic neuralgia patients comparing with ketamine infusion therapy?

Journal of Clinical Anesthesia
Yang Hyun KimTak Kyu Oh

Abstract

Postherpetic neuralgia (PHN) is a frequent debilitating complication and one of the most intractable pain disorders, particularly in elderly patients. Although tricyclic antidepressants, topical capsaicin, gabapentin, and oxycodone are effective for alleviating PHN, many patients remain refractory to current therapies. Here, the analgesic effects of ketamine or magnesium for PHN were assessed in an open prospective study. Thirty patients with severe, intractable PHN who were unresponsive to conservative therapy participated. The effects of ketamine hydrochloride (Ketara, Parke Davis) 1 mg/kg and magnesium sulfate (Magnesin) 30 mg/kg were investigated. The patients were randomly divided into 2 groups of 15 patients each, and ketamine 1 mg/kg or magnesium 30 mg/kg was administered intravenously for 1 hour after midazolam sedation. Pain was rated on a visual analog scale (VAS) during a 2-week follow-up. All patients also completed the Doleur Neuropathique 4 questionnaire at baseline and final visits. Response to treatment, defined as a 50% reduction in VAS score 2 weeks after, was recorded in 10 of 15 patients in the ketamine group and 7 of 15 patients in the magnesium group. The difference in VAS reduction was not significant bet...Continue Reading

References

Sep 1, 1994·The Clinical Journal of Pain·V HoffmannH Adriaensen
Aug 1, 1993·Pain·C F Stannard, G E Porter
Oct 24, 2002·British Journal of Anaesthesia·S BrillP P Di Vadi
Jul 16, 2003·Acta Anaesthesiologica Scandinavica·A KvarnströmT Gordh

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Citations

Jun 19, 2020·Anesthesiology·J David Clark
Aug 8, 2018·American Journal of Veterinary Research·Ludovic TanquerelMathilde Leclere
Jul 29, 2020·Nutrients·Hyun-Jung ShinSang-Hwan Do
Mar 4, 2019·CNS Drugs·Denise Kreutzwiser, Qutaiba A Tawfic
Jul 6, 2021·Anesthesiology and Pain Medicine·Ivan UritsOmar Viswanath

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