Is male factor infertility associated with midlife low-grade inflammation? A population based study

Human Fertility : Journal of the British Fertility Society
Katia Keglberg HærvigLone Schmidt

Abstract

Male factor infertility is associated with an increased risk of disease and mortality, which has been related to markers of chronic systemic inflammation. The objective of this study was to investigate the association between male factor infertility and low-grade inflammation and furthermore to examine the lifetime prevalence of male factor infertility and overall infertility (also including female and couple infertility). The study population consisted of 2140 members of the Metropolit 1953 Danish Male Birth Cohort who had participated in the Copenhagen Aging and Midlife Biobank data collection in 2009-2011. Information on male factor infertility and overall infertility was obtained from a questionnaire, and low-grade inflammation was evaluated as the highest plasma levels of C-reactive protein, interleukin-6 and tumour necrosis factor-alpha in the population. The level of interleukin-6 was significantly higher among men with male factor infertility compared with other men adjusted for potential confounders. This was not found for the two other inflammatory markers. The lifetime prevalence of male factor infertility and overall infertility were 10.2% and 17.9%, respectively. The findings suggest that male factor infertility mi...Continue Reading

References

Feb 3, 2000·Human Reproduction·A G AndersenN E Skakkebaek
May 2, 2001·Human Reproduction·N JørgensenN E Skakkebaek
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Chris J MalkinT Hugh Jones
Sep 16, 2004·Paediatric and Perinatal Epidemiology·Merete OslerBjørn E Holstein
Jul 22, 2005·Journal of Leukocyte Biology·Helle Bruunsgaard
Dec 27, 2005·International Journal of Epidemiology·Merete OslerAnne-Marie Nybo Andersen
Aug 20, 2008·International Journal of Andrology·E MorettiG Collodel
Feb 4, 2009·Psychosomatic Medicine·M Bryant HowrenJerry Suls
Jul 29, 2009·American Journal of Epidemiology·Tina Kold JensenErik Bostofte
Aug 27, 2009·American Journal of Reproductive Immunology : AJRI·Bulent DemirTalip Gul
Sep 23, 2009·Clinical Endocrinology·Varant KupelianJohn B McKinlay
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Srividya SeshadriD I Lewis Jones
Jan 20, 2011·American Journal of Reproductive Immunology : AJRI·Li QianHaoMing He
Jan 19, 2012·Diabetes & Metabolism·M C Calle, M L Fernandez
Aug 15, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·C Mary Schooling
Sep 21, 2013·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Alexander E Omu
Nov 30, 2013·The Urologic Clinics of North America·Brian R Winters, Thomas J Walsh
Mar 4, 2014·Journal of Aging and Health·Kirsten AvlundRikke Lund
Oct 16, 2014·The British Journal of Nutrition·Eirini C SpyridakiAndrew N Margioris
Nov 26, 2014·Nature Reviews. Rheumatology·Fabiana B Benatti, Bente K Pedersen
Jul 27, 2015·International Journal of Epidemiology·Rikke LundMerete Osler

❮ Previous
Next ❯

Citations

Apr 24, 2018·Human Fertility : Journal of the British Fertility Society·Allan A Pacey
Oct 14, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Clara Helene GlazerJens Peter Bonde
Feb 14, 2020·American Journal of Reproductive Immunology : AJRI·Daniel Elieh Ali KomiGerhard Haidl
Apr 4, 2021·International Journal of Molecular Sciences·Daniele SantiManuela Simoni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.