Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis

Oncotarget
Chao HuangZhengli Chen

Abstract

We conducted a systematic review and meta-analysis of observational case-control studies to evaluate markers of oxidative stress in seminal plasma of patients with male infertility. Current evidence links oxidative stress to male infertility, in which multiple markers of oxidative stress have been widely detected, publishing inconsistent results with regard to the role of oxidative stress markers in the evaluation of male infertility. Therefore, a systematic review and meta-analysis on this issue is necessary. From the 1024 articles initially retrieved, 65 studies were included in our meta-analysis with 11 oxidative stress markers, containing 3819 male infertility patients and 2012 controls. The concentrations of malondialdehyde (SMD = 1.86, p < 0.00001), NO (SMD = 0.89, p = 0.001), carbonyl protein (SMD = 2.09, p < 0.00001) in seminal plasma were significantly higher in infertility patients. The concentrations of GSH (SMD = -1.68, p < 0.00001), vitamin C (SMD = -1.12, p < 0.00001), and vitamin E (SMD = -1.48, p = 0.003), as well as the activities of catalase (SMD = -1.91, p < 0.0001), glutathione peroxidase (SMD = -1.96, p = 0.0002) and glutathione-S-transferase (SMD = -1.62, p = 0.009) declined remarkably, resulting in decrea...Continue Reading

References

Jul 1, 1989·Biology of Reproduction·R J AitkenS Fishel
Oct 1, 1989·Gamete Research·C JeulinR Calvayrac
Jan 1, 1984·Methods in Enzymology·H Aebi
Aug 1, 1995·Fertility and Sterility·J B WeinbergA F Haney
Apr 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Aitken, H Fisher
Jun 1, 1996·Human Reproduction·M KurpiszP Jedrzejczak
Aug 1, 1996·Human Reproduction·R SmithE Lissi
Aug 15, 1997·The Journal of Biological Chemistry·B S Berlett, E R Stadtman
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jan 15, 1998·Social Science & Medicine·A L Greil
Jan 30, 2003·Journal of Endocrinological Investigation·A GiannattasioG Lombardi
May 17, 2003·Fertility and Sterility·Ashok AgarwalMohamed A Bedaiwy
Aug 2, 2003·Archives of Andrology·Y KocaN Balaban
Aug 23, 2003·Biostatistics·J Copas, J Q Shi
Jun 1, 2004·Reproductive Biomedicine Online·Ashok AgarwalTamer M Said
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Jul 17, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ke LiYonggang Chen
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·John D HayesIan R Jowsey
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Heidar TavilaniHojatollah Saeidi
Jan 18, 2006·Molecular and Cellular Endocrinology·R John Aitken, Mark A Baker
Jan 18, 2006·Urology·Ashok AgarwalShyam Allamaneni
Aug 17, 2006·Archives of Gynecology and Obstetrics·Fatma Ferda VeritMete Koksal
Oct 10, 2006·Fertility and Sterility·Ashok AgarwalSuresh C Sikka
Jun 2, 2007·BMC Clinical Pathology·Ali Khosrowbeygi, Nosratollah Zarghami
Aug 3, 2007·Fertility and Sterility·Shu-Huei KaoYau-Huei Wei
Feb 19, 2008·Human Reproduction Update·Kelton Tremellen
Mar 4, 2008·Fertility and Sterility·Reda MahfouzAshok Agarwal
Sep 10, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Heidar TavilaniTaghi Hassanzadeh
Oct 22, 2008·Fertility and Sterility·Nisarg DesaiAshok Agarwal
Mar 17, 2009·Journal of Clinical Laboratory Analysis·Fatma Ben AbdallahLeila Ammar-Keskes
Mar 20, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Moustafa A A El-TaiebMichael Marberger
Apr 29, 2009·Biochimica Et Biophysica Acta·Yi-Shing MaYau-Huei Wei

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Citations

Feb 9, 2020·Antioxidants·Karolina Nowicka-Bauer, Brett Nixon
May 20, 2020·Andrologia·Marwan AliNeel Parekh
Jul 15, 2020·Andrologia·Marlon Martinez, Ahmad Majzoub
Jan 5, 2021·Frontiers in Veterinary Science·Omid FarshadMohammad Mehdi Ommati
Jun 3, 2021·Clinical and Experimental Reproductive Medicine·Ahmed T AlahmarAldo E Calogero

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