Is mammographic breast density a breast cancer risk factor in women with BRCA mutations?

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kavitha PassaperumaM J Yaffe

Abstract

Increased mammographic breast density is well recognized as a breast cancer risk factor in the general population. However, it is unclear whether it is a risk factor in women with BRCA mutations. We present the results of a nested case-control screening study investigating the relationship between breast density and breast cancer incidence in this population. Women ages 25 to 65 years with known BRCA mutations were enrolled onto a single-center, high-risk breast cancer screening program. Using a computer-aided technique (Cumulus), quantitative percentage density (PD) was measured for each participant on her baseline mammogram by a single, blinded observer. Between November 1997 and March 2008, 462 women (mean age, 44 years; 245 BRCA1 and 217 BRCA2) were screened and 50 breast cancers were diagnosed (38 invasive, 12 ductal carcinoma in situ [DCIS]). Density was not measured in 40 women of whom four developed cancer (three invasive, one DCIS). Mean PD (+/- standard deviation [SD]) for 376 women who did not develop breast cancer was 34% (23) compared with 31% (21) for 46 women with cancer (P = .51). Logistic regression model of breast cancer incidence and PD revealed an odds ratio of 0.99 (+/- 0.01 SD) for a one-unit increase in P...Continue Reading

References

Jun 1, 1987·Physics in Medicine and Biology·P C Johns, M J Yaffe
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
Jul 1, 1997·Breast Cancer Research and Treatment·J N MarcusH T Lynch
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M RobsonK Offit
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A Blackwood, B L Weber
Jan 14, 1999·The New England Journal of Medicine·L C HartmannR B Jenkins
Aug 19, 1999·Journal of the National Cancer Institute·N F BoydD L Tritchler
Sep 2, 1999·Journal of the National Cancer Institute·T R RebbeckB L Weber
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E WarnerS A Narod
Sep 16, 2004·JAMA : the Journal of the American Medical Association·Ellen WarnerSteven A Narod
Oct 1, 1994·Physics in Medicine and Biology·J W ByngM J Yaffe
Feb 3, 2006·Cancer Research·Gillian MitchellDouglas F Easton
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Norman F BoydSalomon Minkin
Jan 19, 2007·The New England Journal of Medicine·Norman F BoydMartin J Yaffe
Sep 25, 2008·Journal of the National Cancer Institute·Andrea EisenUNKNOWN Hereditary Breast Cancer Clinical Study Group

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Citations

Feb 18, 2011·European Radiology·Sanaz A JansenGillian M Newstead
Jan 10, 2012·Breast Cancer Research and Treatment·Christy G WoolcottGertraud Maskarinec
Mar 13, 2014·Breast Cancer Research and Treatment·C W HuoE W Thompson
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Claire M Perks, Jeff M P Holly
Jul 15, 2015·Breast Cancer Research : BCR·Teresa Ramón Y CajalMarina Pollán
May 15, 2012·European Journal of Radiology·Bin ZhengDavid Gur
Aug 17, 2016·Endocrine-related Cancer·Roger L Milne, Antonis C Antoniou
Jul 21, 2017·International Journal of Computer Assisted Radiology and Surgery·Shiju YanBin Zheng
May 31, 2018·Cancer Biomarkers : Section a of Disease Markers·Yu JiPeifang Liu

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