Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?

Antioxidants & Redox Signaling
Vesna OtaševićBato Korac

Abstract

Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide ((•)NO), the number of MitoTracker(®) Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as (•)NO might be involved in the observed effects of the mimic.

References

Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Oct 3, 2003·British Journal of Pharmacology·Carolina MuscoliDaniela Salvemini
Mar 10, 2009·Free Radical Biology & Medicine·Eve de LamirandeMichèle Villemure
May 6, 2009·Human Reproduction Update·João Ramalho-SantosAlexandra Amaral
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Miomir JovicBato Korac

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Citations

Oct 3, 2013·Brain Research Bulletin·Ana StančićBato Korać
Dec 4, 2014·Animal Reproduction Science·D S R AngrimaniC I Vannucchi
Sep 3, 2014·Andrology·M S RahmanM-G Pang
Mar 8, 2014·British Journal of Pharmacology·B BuzadzicV Otasevic
Oct 30, 2016·Reproductive Biomedicine Online·Yang YangLan Chao
Sep 7, 2016·Free Radical Research·Aleksandra JankovicBato Korac
Nov 12, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kerem TakenMehmet Ramazan Sekeroglu
Jun 19, 2012·Antioxidants & Redox Signaling·Alexandra Amaral, João Ramalho-Santos
Aug 21, 2013·Chemical Communications : Chem Comm·Adi HaberZeev Gross
Aug 23, 2019·Animal Biotechnology·Roberto R da Rosa FilhoCristina F Lucio

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Methods Mentioned

BETA
PCR

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