Is maternal microbial metabolism an early-life determinant of health?

Lab Animal
Kymberleigh A Romano, Federico E Rey

Abstract

Mounting evidence suggests that environmental stress experienced in utero (for example, maternal nutritional deficits) establishes a predisposition in the newborn to the development of chronic diseases later in life. This concept is often referred to as the "fetal origins hypothesis" or "developmental origins of health and disease". Since its first proposal, epigenetics has emerged as an underlying mechanism explaining how environmental cues become gestationally "encoded". Many of the enzymes that impart and maintain epigenetic modifications are highly sensitive to nutrient availability, which can be influenced by the metabolic activities of the intestinal microbiota. Therefore, the maternal microbiome has the potential to influence epigenetics in utero and modulate offspring's long-term health trajectories. Here we summarize the current understanding of the interactions that occur between the maternal gut microbiome and the essential nutrient choline, that is not only required for fetal development and epigenetic regulation but is also a growth substrate for some microbes. Bacteria able to metabolize choline benefit from the presence of this nutrient and compete with the host for its access, which under extreme conditions may ...Continue Reading

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Citations

Aug 29, 2020·Applied Microbiology and Biotechnology·Cigdem Celiker, Rasime Kalkan
Feb 6, 2020·Frontiers in Genetics·Manvi SharmaTrygve O Tollefsbol
Aug 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Faye ChleilatRaylene A Reimer

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Methods Mentioned

BETA
histone acetylation

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