Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM)

PloS One
Amir AhmadiJames K Min

Abstract

Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did n...Continue Reading

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Citations

Sep 25, 2017·Journal of Circulating Biomarkers·Alexander E BerezinYu Martovitskaya
Dec 5, 2018·BMC Emergency Medicine·Asma Sriha BelguithUNKNOWN ESCorT Investigators group
Oct 22, 2020·Internal and Emergency Medicine·Giovanni CioffiAlessandro Giollo
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Nov 27, 2020·International Journal of Environmental Research and Public Health·Jinsun KimByungmi Kim
Dec 9, 2020·Scientific Reports·Stephen EllisonSvati H Shah
Jan 4, 2021·Breast Cancer Research and Treatment·Kaitlyn KennardNed Z Carp
Feb 17, 2021·Journal of Medical Imaging and Radiation Oncology·Mark A AndersonAvinash Kambadakone
Mar 7, 2021·International Journal of Environmental Research and Public Health·Amal F AlshammaryImran Ali Khan
Nov 28, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Seo Rin Kim, Lilach O Lerman
Jul 22, 2021·Journal of Cardiovascular Translational Research·Jill K BadinMichael Sturek

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