Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A Critically Appraised Topic

The British Journal of Dermatology
R BrowneH C Williams

Abstract

Is methotrexate (MTX) an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? Alopecia areata (AA) is a common disorder causing nonscarring hair loss with an estimated lifetime prevalence of approximately 2%. Treatment of extensive AA is challenging. The aim of this Critically Appraised Topic was to assess the current evidence regarding use of MTX for inducing and maintaining hair growth in patients with alopecia totalis. We critically appraised the literature identified from searching PubMed, Ovid MEDLINE, Ovid Embase and Cochrane Central (October 2017), using the search terms ("alopecia areata" OR "alopecia totalis" OR "alopecia universalis") AND (methotrexate). Two prospective studies and 11 retrospective case series were included, comprising 226 patients with alopecia varying from 30% hair loss to alopecia universalis at baseline. MTX was usually given with systemic corticosteroids for induction of hair regrowth rather than regrowth maintenance. Regrowth, defined as anything from 50% to complete regrowth, was reported in 20-90% of patients. Relapse occurred in 20-80%, with variable regrowth on retreatment. Most series were small, with limited methodological detail and follow-up data. A...Continue Reading

References

Nov 1, 1989·Clinical and Experimental Dermatology·F B De Waard-van der SpekJ D Peereboom-Wynia
Sep 1, 2004·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN National Alopecia Areata Foundation
Jun 1, 1950·The Journal of Investigative Dermatology·S A WALKER, S ROTHMAN
Oct 22, 2005·BMJ : British Medical Journal·Nigel Hunt, Sue McHale
Aug 16, 2006·Journal of the American Academy of Dermatology·Antonella TostiMatilde Iorizzo
Apr 27, 2011·The British Journal of Dermatology·M RoyerJ Mazereeuw
Apr 25, 2012·The British Journal of Dermatology·A G MessengerM Sladden
Jun 29, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Catherine DroitcourtJulien Seneschal
Sep 4, 2014·Anais Brasileiros De Dermatologia·Mariana Hammerschmidt, Fabiane Mulinari Brenner
Jun 16, 2015·Acta Dermato-venereologica·Philippine LucasJuliette Mazereeuw-Hautier
Oct 30, 2015·The British Journal of Dermatology·R A KuinE J van Zuuren
Jan 7, 2016·Dermatology : International Journal for Clinical and Investigative Dermatology·Delphine AnusetZiad Reguiai
Jan 19, 2016·Journal of the American Academy of Dermatology·Rony Shreberk-HassidimAbraham Zlotogorski
Feb 26, 2016·The British Journal of Dermatology·F RenczV Brodszky
Apr 18, 2016·Journal of the American Academy of Dermatology·Sergio Vañó-GalvánPedro Jaén
Mar 17, 2017·Nature Reviews. Disease Primers·C Herbert PrattJohn P Sundberg
Apr 6, 2017·International Journal of Dermatology·Sama KassiraFrancis Dann
Apr 21, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J H ChongF Boralevi
Jun 2, 2017·Annals of Dermatology·Seul-Ki LimYoung Lee
Jun 22, 2017·The Journal of Dermatology·Solam Lee, Won-Soo Lee
Jun 25, 2017·Advances in Therapy·Yael Renert-Yuval, Emma Guttman-Yassky
Sep 25, 2017·The Journal of Dermatology·Salim AlkerayeDelphine Staumont-Sallé
Dec 16, 2017·Journal of the American Academy of Dermatology·Lauren C StrazzullaJerry Shapiro

❮ Previous
Next ❯

Citations

May 21, 2020·Molecular Pharmaceutics·Guang YangZhen Gu
Mar 16, 2021·Journal of Cutaneous Medicine and Surgery·Misaki Kinoshita-IsePerla Lansang
Mar 30, 2021·Journal of Cosmetic Dermatology·Mohamed L Elsaie, Mohamed S Hasan
Feb 9, 2020·Annales de dermatologie et de vénéréologie·E Delaporte
Jan 19, 2022·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dimitra Aikaterini LintzeriUlrike Blume-Peytavi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.