Is milk-borne insulin-like growth factor-I essential for neonatal development?

The Journal of Nutrition
Douglas G Burrin

Abstract

Insulin-like growth factor-I (IGF-I), a polypeptide growth factor found in milk, is hypothesized to play a functional role in the growth and development of neonates, particularly the gastrointestinal tract. Considerable evidence, based on direct tracer studies with 125I-labeled IGF-I and measurements of circulating IGF-I concentrations in neonatal animals fed a range of IGF-I doses, indicates that the intestinal absorption of IGF-I and the possible effect on metabolism and somatic growth are negligible. However, studies in neonatal animals indicate that oral administration of pharmacological doses of IGF-I increases small intestinal mucosal growth, whereas oral IGF-I provided within the physiological range may enhance the development of intestinal lactase. Therefore, clinical trials exploring the therapeutic use of oral IGF-I as an intervention for preterm neonates and those with compromised intestinal function seem warranted. However, milk-borne IGF-I may not be essential for normal healthy infants, perhaps because endogenous IGF-I provides a sufficient stimulus for maintenance of gastrointestinal structure and function. Future studies should explore the significance of endogenous IGF-I and whether milk-borne IGF-I may be impo...Continue Reading

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Citations

Aug 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·A F PhilippsO Koldovský
May 19, 2000·Journal of Pediatric Gastroenterology and Nutrition·T KinouchiT Yajima
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Anthony F PhilippsBohuslav Dvorák
Dec 13, 2003·Critical Reviews in Food Science and Nutrition·Arun Kilara, Dinakar Panyam
Dec 24, 2005·Journal of the American College of Nutrition·Peter W Parodi
Jan 23, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Marijke OsteChrista J Van Ginneken
Aug 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·T KinouchiT Yajima
Jun 9, 2009·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Jessica G WooArdythe L Morrow
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Apr 12, 2000·Journal of the American College of Nutrition·C BosD Tomé
Nov 29, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Andrea S Wiley

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