Is minimally invasive esophagectomy effective for preventing anastomotic leakages after esophagectomy for cancer? A systematic review and meta-analysis

World Journal of Surgical Oncology
Can ZhouYu Ren

Abstract

Compared with open esophagectomy (OE), minimally invasive esophagectomy (MIE) proves to have clear benefits in reducing the risk of pulmonary complications for patients with resectable esophageal cancer. The objectives of our study were to explore the superiority of MIE in reducing the occurrence of anastomotic leakages (ALs) when compared to OE. A systematic review and meta-analysis was performed to assess the superiority of MIE on the occurrence of ALs over OE, by searching many sources (through December, 2014) such as Medline, Embase, Wiley Online Library, and Cochrane Library. Fixed-effects model was used to calculate summary odds ratios (ORs) to quantify associations between OE and MIE groups. Cochran's Q and I(2) statistics were used to evaluate heterogeneity among studies. Among a total of 43 studies involving 5537 patients included in the meta-analysis, 2527 (45.6%) cases underwent MIE and 3010 (54.4%) cases underwent OE. Compared to patients undergoing OE, patients undergoing MIE did not have statistical significance in reduced occurrence of ALs (OR = 0.97, 95% CI = 0.80-1.17). Insignificant reduced occurrence of ALs was not associated with anastomotic location (OR = 0.90, 95% CI = 0.71-1.13) or anastomotic procedure (...Continue Reading

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Citations

Jul 13, 2016·Langenbeck's Archives of Surgery·Danica N GiuglianoFrancesco Palazzo
Oct 4, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Michele ValmasoniStefano Merigliano
Dec 9, 2016·World Journal of Surgical Oncology·Waresijiang YibulayinWei Sun
Oct 8, 2020·Langenbeck's Archives of Surgery·C MannP P Grimminger
Dec 11, 2020·Indian Journal of Surgical Oncology·Subramanyeshwar Rao ThammineediSyed Nusrath

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