Is MK-801 neuroprotection mediated by systemic hypothermia in the immature rat?

Neuroreport
E Gilland, Henrik Hagberg

Abstract

Hypothermia after hypoxia-ischaemia (HI) confounds the interpretation of the effects of neuroprotective drug intervention. The effect of 0.5 mg/kg of dizocilpine (MK-801) administered after HI on rectal temperature at 2-36 h and on brain damage 2 weeks after the insult was evaluated in the immature rat. In pups kept at an ambient temperature of 21 degrees C, MK-801 lowered the temperature by 1.1 degrees C and reduced the brain damage by 45%. In pups held at an ambient temperature of 33 degrees C, MK-801 treatment afforded a 34% reduction of brain damage without lowering the rectal temperature. In conclusion, the neuroprotection offered by MK-801 does not depend on systemic hypothermia in this model.

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Citations

Nov 19, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Yasunori ChoRyohei Yozu
Dec 14, 1999·Journal of Neuroscience Methods·A M BrambrinkO Kempski
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Jul 23, 2003·Journal of Neurochemistry·Xiaoyang WangKlas Blomgren
Apr 22, 2010·Basic & Clinical Pharmacology & Toxicology·Mohsen NateghMojdeh Ghabaei
Mar 4, 2006·Neurochemistry International·Dorota MakarewiczJerzy W Łazarewicz
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg

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