PMID: 696344Aug 1, 1978Paper

Is moderate ethanol consumption teratogenic in the rat?

Acta Pharmacologica Et Toxicologica
J F OisundJ Mørland

Abstract

Female Wistar rats were given ethanol in their drinking fluid to cover 20-25% of the total calories consumed for 3-4 weeks prior to, during and also after pregnancy in some experiments. Soya oil was substituted for ethanol isocalorically in the control groups. Apart from a statistically significant reduction in litter size based on the number of apparent normal foetuses at intrauterine examination, no significant changes in reproductive performance could be recorded after ethanol treatment. In the offspring, examined up to 24 days of age, the body and some viscera weights were statistically significantly higher at some stages from 2 to 14 days. The general trend, however, showed that there were no significant differences in body, brain, liver, kidney, and heart muscle weights between control and ethanol offspring measured in rats between 0 and 24 days of age. Two gross malformations were recorded among 321 pups of ethanol treated mothers, whereas no malformations were found in 444 control pups. It was concluded that moderate ethanol consumption by rat mothers for 3-4 weeks before and during pregnancy as well as during the suckling period, had no serious effects on their reproductive performance and the development of their offs...Continue Reading

References

Nov 1, 1975·Journal of Studies on Alcohol·R H Warner, H L Rosett
Jun 1, 1977·Teratology·G F Chernoff
Nov 1, 1976·Journal of Studies on Alcohol·J Yanai, B E Ginsburg
Jan 1, 1976·Annals of the New York Academy of Sciences·A K Rawat
Apr 1, 1976·American Journal of Obstetrics and Gynecology·J B Kronick
May 1, 1976·The Journal of Nutrition·J J Wurtman, S A Miller
Mar 15, 1973·American Journal of Obstetrics and Gynecology·E Cobo
Mar 1, 1974·American Journal of Obstetrics and Gynecology·H G Green
Nov 1, 1969·Acta Endocrinologica·A R Fuchs
Jan 1, 1967·Acta Pharmacologica Et Toxicologica·L Pilström, K H Kiessling

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Citations

May 1, 1986·Neuropathology and Applied Neurobiology·D Lopez-TejeroE Herrera
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·K FernandezR C Michaelis
Aug 1, 1982·Journal of Toxicology and Environmental Health·R F MankesR Abraham
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·R F Mankes, S D Glick
Dec 1, 1979·Mutation Research·G Obe, H Ristow
Jul 1, 1984·Drug and Alcohol Dependence·A W Chan

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