Is moderate substance use associated with altered executive functioning in a population-based sample of young adults?

Human Psychopharmacology
Michaela PiechatzekChristian G Schütz

Abstract

Substance use (SU) has been linked with impaired cognitive functioning. Evidence comes mainly from clinical studies or studies examining heavy users. Though, the majority of users are not involved in heavy use. This study investigates the association between moderate use and cognition in a population-based sample. A total of 284 young adults with ecstasy, cannabis or alcohol use and a control group were sampled from the EDSP database for participation in the Munich Assessment of Young Adults (MAYA) study. Subjects completed a comprehensive battery of neuropsychological tests (executive functions, working memory and impulsivity). Multiple linear regression models were conducted to examine the relationship between use and cognitive performance. Increased ecstasy consumption was associated with increased error-proneness (Stroop task, CANTAB ID/ED-shift, spatial working memory). More frequent cannabis use and more extensive alcohol consumption were associated with a higher degree of impulsiveness. Based on mild to moderate SU, little indication of differences in executive functioning was found. For ecstasy use, an increased error-proneness was revealed. The subtle differences in relatively young individuals warrant further investig...Continue Reading

References

Aug 1, 1990·Journal of Abnormal Psychology·M E Bates, J I Tracy
Jan 1, 1990·Neuropsychologia·A M OwenT W Robbins
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice
Dec 1, 1982·Perceptual and Motor Skills·M RegardP Knapp
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Jul 1, 1996·Neurotoxicology and Teratology·P J Fray, T W Robbins
Nov 1, 1996·Archives of General Psychiatry·J M FletcherP Satz
Jan 1, 1997·Journal of Substance Abuse·T L Waldeck, L S Miller
May 19, 1998·Journal of Psychopharmacology·A C ParrottK Wesnes
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·O A Parsons
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M J Morgan
Sep 19, 1998·European Addiction Research·H U WittchenC B Nelson
Sep 19, 1998·European Addiction Research·P SchusterH U Wittchen
Dec 17, 1998·Neurology·K I BollaG A Ricaurte
Jul 31, 1999·Drug and Alcohol Dependence·A Bauman, P Phongsavan
Sep 4, 1999·Journal of Psychopharmacology·J Evenden
Sep 18, 1999·American Journal of Epidemiology·P K EliasP A Wolf
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Nov 7, 1999·Psychopharmacology·J L Evenden
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·E Gouzoulis-MayfrankH Sass
Jun 1, 2000·British Journal of Psychology·M WareingP N Murphy
Jul 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T J OrnsteinT W Robbins
Aug 25, 2000·Psychopharmacology·J Rodgers
Dec 22, 2000·European Addiction Research·R LiebH U Wittchen
Feb 24, 2001·Psychopharmacology·R J VerkesA F Cohen
Mar 29, 2001·Psychopharmacology·R J CroftJ G Gruzelier
Apr 13, 2001·Current Opinion in Neurobiology·R D Rogers, T W Robbins
Aug 29, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·H F MoselhyA Kahn
Nov 1, 2001·Archives of General Psychiatry·H G PopeD Yurgelun-Todd
Dec 26, 2001·Archives of General Psychiatry·X NoëlP Verbanck
Dec 26, 2001·Annual Review of Psychology·Donald T Stuss, Brian Levine
Mar 7, 2002·JAMA : the Journal of the American Medical Association·Nadia SolowijUNKNOWN Marijuana Treatment Project Research Group

❮ Previous
Next ❯

Citations

Feb 4, 2012·Psychopharmacology·Denis T GallagherPaul J Taylor
Apr 12, 2012·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Judith S BrookStephen J Finch
Mar 24, 2012·Journal of Clinical and Experimental Neuropsychology·Merel F H Griffith-LenderingHanna Swaab
Dec 24, 2011·American Journal of Epidemiology·Alex Dregan, Martin C Gulliford
Jun 21, 2014·The American Journal of Drug and Alcohol Abuse·Daniela L CannizzaroEfrat Aharonovich
Oct 19, 2011·Alcoholism, Clinical and Experimental Research·Scott J HaytonMary C Olmstead
Aug 5, 2011·International Journal of Methods in Psychiatric Research·Peggy van der PolMargriet van Laar
Apr 30, 2015·Psychopharmacology·Jenessa S PriceKrista M Lisdahl
Mar 20, 2012·Drug and Alcohol Dependence·Margarita MorenoPilar Flores
Sep 3, 2013·Drug and Alcohol Dependence·Leanne TammUNKNOWN MTA Neuroimaging Group
Oct 23, 2015·Brain Imaging and Behavior·Jerod RasmussenUNKNOWN MTA Neuroimaging Group
Mar 24, 2017·International Journal of Environmental Research and Public Health·Thabang ManyaapeloPriscilla Reddy
Sep 19, 2017·The American Journal on Addictions·James MckowenTimothy Wilens
Jan 25, 2018·Journal of the International Neuropsychological Society : JINS·Laura J GrandeRegina E McGlinchey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Michael John MorganRobert David Rogers
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Liesbeth RenemanJan Booij
Drug and Alcohol Dependence
G K L Butler, A M J Montgomery
© 2022 Meta ULC. All rights reserved