Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study

Clinical Therapeutics
Yaron FinkelsteinGideon Koren

Abstract

Recurrent painful vaso-occlusive crises (VOC) are a hallmark of sickle cell disease (SCD), and narcotic analgesics are an effective component of therapy. However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain. The aim of this study was to explore the potential association between a dose-response effect of morphine exposure and the development of ACS in children with SCD who presented with VOC. A retrospective, self-matched, case-crossover design was used to study data from children with SCD who were treated with continuous-drip IV morphine (initial rate of 10 mug/kg . h) for VOC and subsequently developed ACS (index hospitalization) at a tertiary pediatric hospital in Toronto, Ontario, Canada, from April 1, 2000, to March 31, 2006. So that each child could serve as his or her own control for the analysis, a comparison hospitalization for VOC was identified for each child during which ACS did not develop (reference hospitalization). We determined the cumulative dose of morphine administered before ACS development (index interval) during the index hospitalization and the cumulative amount of morphine administered during the same time interval during the re...Continue Reading

Citations

Apr 26, 2013·Journal of Palliative Medicine·Caterina P MinnitiHunter Groninger
Dec 18, 2013·Hospital Pediatrics·Catherine S BirkenPatricia C Parkin
Oct 15, 2008·Peptides·Richard J Bodnar
Sep 14, 2013·Pharmacoepidemiology and Drug Safety·Giulia P ConsiglioSuzanne M Cadarette
Apr 1, 2015·British Journal of Haematology·Jo HowardUNKNOWN BCSH Committee
May 5, 2010·Current Opinion in Supportive and Palliative Care·Josh Wright, Sam H Ahmedzai
Aug 29, 2020·The Journal of the American Osteopathic Association·Ashley Griswold HaggertyKenneth D Katz
Jul 25, 2020·Current Pain and Headache Reports·Mariam Salisu OrhurhuVwaire Orhurhu
Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Claire ArbitreEvelyne D Trottier
May 14, 2009·Current Opinion in Supportive and Palliative Care

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