Apr 25, 2020

3D SYNAPTIC ORGANIZATION OF THE RAT CA1 AND ALTERATIONS INDUCED BY COCAINE SELF-ADMINISTRATION

BioRxiv : the Preprint Server for Biology
Lidia Blazquez-LlorcaJ. DeFelipe

Abstract

The hippocampus plays a key role in contextual conditioning and has been proposed as an important component of the cocaine addiction brain circuit. To gain knowledge about cocaine-induced alterations in this circuit, we used Focused Ion Beam milling/Scanning Electron Microscopy (FIB/SEM) to reveal and quantify the 3D synaptic organization of the stratum radiatum of rat CA1, under normal circumstances and after cocaine-self administration (SA). Most synapses are asymmetric (excitatory), macular-shaped, and in contact with spine heads. After cocaine-SA, the size and complexity of both asymmetric and symmetric (inhibitory) synapses increased but no changes were observed in the synaptic density. This work constitutes the first detailed report on the 3D synaptic organization in the stratum radiatum of the CA1 field of cocaine-SA rats. Our data contribute to the elucidation of the normal and altered synaptic organization of the hippocampus, which is crucial for better understanding the neurobiological mechanisms underlying cocaine addiction.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Literature
Research

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Vestnik Rossiĭskoĭ akademii meditsinskikh nauk
A M IzutkinG I Tsaregorodtsev
Voprosy okhrany materinstva i detstva
K E TarasovE K Chernenko
Psychiatric Research Reports
A KAPLAN
Acta Biologica Academiae Scientiarum Hungaricae
J Horváth
© 2020 Meta ULC. All rights reserved