Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis

F1000Research
Huaxiang ZhaoJiuxiang Lin

Abstract

To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P). An extensive literature review has been conducted using PubMed, Web of Science, Cochrane Library, Google Scholar, the China National Knowledge Infrastructure (CNKI), and Wanfang Database for eligible researches. The terms for searching were "cleft lip OR cleft palate OR CLP OR CL/P OR oral facial cleft OR OFC" AND "methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 OR methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase OR MTHFD1 OR MTHFD". Two independent researchers screened, evaluated and extracted the data of included studies. The pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated by random effects model under five gene models. Subgroup, sensitivity analysis and publication bias were also assessed. Ten case-control studies have been included in the systematic review and eight studies have been considered for the meta-analysis. Overall, the MTHFD1 polymorphism rs2236225 and the risk of NSCL/P showed pooled OR (95% CI) of 1.02 (0.86-1.21) under allelic model. A high...Continue Reading

References

Feb 1, 1994·Journal of Medical Genetics·D R FitzPatrickJ G Boorman
Mar 1, 1997·Annals of Internal Medicine·D J CookR B Haynes
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards for Reporting of Trials)
Jul 5, 2001·Journal of Clinical Epidemiology·D F StroupL Hutwagner
May 29, 2002·Clinical Genetics·J C Murray
Dec 4, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Andrew C Lidral, Jeffrey C Murray
Jun 16, 2005·Bioinformatics·Elias Zintzaras, John P A Ioannidis
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Jaime L PetersLesley Rushton
Dec 21, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Mahsa M YazdyJian Xing
Jan 19, 2008·American Journal of Medical Genetics. Part a·Abee L BoylesRolv Terje Lie
Jun 28, 2008·International Journal of Epidemiology·Candice Y Johnson, Julian Little
Jul 12, 2008·BMC Medical Research Methodology·James Thomas, Angela Harden
Jul 29, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·James L MillsPeadar N Kirke
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Sep 10, 2009·Journal of Medical Genetics·Adrianna MostowskaPawel P Jagodzinski
Sep 15, 2009·Lancet·Peter A MosseyWilliam C Shaw
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Andreia BufalinoRicardo D Coletta
Jan 22, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Susan H BlantonJacqueline T Hecht
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
Oct 25, 2011·BMJ Open·Bruno R da CostaMatthias Egger
Jul 6, 2012·Statistics in Medicine·Dan JacksonRichard D Riley
Nov 28, 2012·BMC Pediatrics·George L WehbyJeffrey C Murray
Mar 20, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Gregory Robinson
Sep 28, 2013·Perspectives on Medical Education·Joule J Li
Nov 21, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sibele Nascimento de AquinoRicardo D Coletta
Jan 2, 2014·International Journal of Pediatric Otorhinolaryngology·Jyotsna MurthyBhaskar V K S Lakkakula
Aug 19, 2014·Medicina oral, patología oral y cirugía bucal·Jyotsna MurthyBhaskar V K S Lakkakula
Nov 27, 2014·Plastic and Reconstructive Surgery. Global Open·Rochelle R KlingEthylin Wang Jabs

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