Is multiple system atrophy with cerebellar ataxia (MSA-C) like spinocerebellar ataxia and multiple system atrophy with parkinsonism (MSA-P) like Parkinson's disease? - A saccade study on pathophysiology

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Yasuo TeraoYoshikazu Ugawa

Abstract

Patients with multiple system atrophy (MSA) are classified into those mainly manifesting cerebellar ataxia (MSA-C) and those mainly manifesting parkinsonism (MSA-P). Pathophysiological bases of these subtypes remain unclear. We hypothesized that MSA-C patients would resemble spinocerebellar degeneration patients and MSA-P patients would resemble Parkinson's disease (PD) patients in saccade abnormalities. We recorded visually guided and memory guided saccades (MGS) in 27 MSA-C and 15 MSA-P patients, as well as 50 age-matched normal subjects, 14 spinocerebellar degeneration patients showing pure cerebellar symptoms (SCD) and 61 Parkinson's disease (PD) patients. Saccade parameters of both tasks showed similar changes with progressing disease in SCD and MSA-C patients, as did those of MSA-C and MSA-P patients, although hypometria was slightly more pronounced in MSA-P. In both subtypes of MSA, latency and success rate of MGS were stable throughout disease stages, whereas they deteriorated progressively with progressing disease in PD. Pathophysiology underlying MSA-C and MSA-P is similar as viewed from saccade performance. The MGS performance in MSA was preserved. However, MSA-P patients showed more marked hypometria, suggesting a m...Continue Reading

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Citations

Sep 1, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hideyuki Matsumoto
Jul 16, 2016·The Clinical Neuropsychologist·Erin E RobertsonJoan A O'Keefe
Oct 13, 2017·Expert Review of Neurotherapeutics·Kurt A Jellinger
Jan 28, 2017·Frontiers in Neuroscience·Yasuo TeraoYoshikazu Ugawa
Dec 12, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yasuo TeraoOkihide Hikosaka
Dec 1, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shin-Ichi TokushigeYasuo Terao
Feb 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yasuo TeraoYoshikazu Ugawa

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