Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors?

Journal of Neurology, Neurosurgery, and Psychiatry
Paul WalkerFrançois Brunotte

Abstract

This retrospective study investigated the dependence of N-acetyl aspartate (NAA) ratios on risk factors for cerebral vasculopathy such as sex, age, hypertension, diabetes mellitus, carotid stenosis, and dyslipidaemia, which may have affected brain vessels and induced metabolic brain abnormalities prior to stroke. We hypothesise that in stroke patients metabolic alterations in the apparently normal contralateral brain are dependent on the presence or not of such risk factors. Fifty nine patients (31 male, 28 female: 58.8+/-16.1 years old) with cortical middle cerebral artery (MCA) territory infarction were included. Long echo time chemical shift imaging spectroscopy was carried out on a Siemens 1.5 T Magnetom Vision scanner using a multi-voxel PRESS technique. Metabolite ratios (NAA/choline, NAA/creatine, lactate/choline, etc) were studied using uni- and multivariate analyses with respect to common risk factors. The influence of age, stroke lesion size, and time since stroke was studied using a linear regression approach. Age, sex, and hypertension all appeared to individually influence metabolite ratios, although only hypertension was significant after multivariate analysis. In both basal ganglia and periventricular white matte...Continue Reading

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Dec 31, 2002·Clinical Imaging·Douraied Ben SalemFrançois Brunotte

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Citations

Nov 23, 2006·Current Diabetes Reports·Dinesh Selvarajah, Solomon Tesfaye
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Douraied Ben SalemFrançois Brunotte
Jan 10, 2013·Neurorehabilitation and Neural Repair·Sorin C CraciunasCarmen M Cirstea
May 12, 2012·Brain Research·Carmen M CirsteaWilliam M Brooks
Oct 29, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Douraied Ben SalemFrançois Brunotte
Nov 3, 2012·Neurobiology of Aging·Natalie M ZahrAdolf Pfefferbaum

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