Is natural variability in gait sufficient to initiate spontaneous energy optimization in human walking?

Journal of Neurophysiology
Jeremy D WongJ Maxwell Donelan

Abstract

In new walking contexts, the nervous system can adapt preferred gaits to minimize energetic cost. During treadmill walking, this optimization is not usually spontaneous but instead requires experience with the new energetic cost landscape. Experimenters can provide subjects with the needed experience by prescribing new gaits or instructing them to explore new gaits. Yet in familiar walking contexts, people naturally prefer energetically optimal gaits: the nervous system can optimize cost without an experimenter's guidance. Here we test the hypothesis that the natural gait variability of overground walking provides the nervous system with sufficient experience with new cost landscapes to initiate spontaneous minimization of energetic cost. We had subjects walk over paths of varying terrain while wearing knee exoskeletons that penalized walking as a function of step frequency. The exoskeletons created cost landscapes with minima that were, on average, 8% lower than the energetic cost at the initially preferred gaits and achieved at walking speeds and step frequencies that were 4% lower than the initially preferred values. We found that our overground walking trials amplified gait variability by 3.7-fold compared with treadmill wa...Continue Reading

References

Jan 1, 1974·European Journal of Applied Physiology and Occupational Physiology·M Y ZarrughH J RALSTON
Jun 21, 1997·Journal of Theoretical Biology·A E Minetti, R M Alexander
Feb 12, 1998·Experimental Brain Research·F DanionJ Pailhous
Apr 26, 2001·Journal of Theoretical Biology·J E Bertram, Andy Ruina
Jul 31, 2001·Journal of Biomechanical Engineering·A D Kuo
Sep 22, 2001·Current Biology : CB·Daniel M Wolpert, J Randall Flanagan
Sep 26, 2001·Proceedings. Biological Sciences·J Maxwell DonelanA D Kuo
Jan 1, 1958·Internationale Zeitschrift für angewandte Physiologie, einschliesslich Arbeitsphysiologie·H J RALSTON
May 28, 2005·Obesity Research·Raymond C Browning, Rodger Kram
Dec 22, 2009·Physical Therapy·Arthur D Kuo, J Maxwell Donelan
Apr 20, 2010·Journal of Biomechanics·L C HunterJ C Dean
Oct 5, 2010·Journal of Neurophysiology·Dinant A KistemakerPaul L Gribble
Oct 29, 2011·Nature Reviews. Neuroscience·Daniel M WolpertJ Randall Flanagan
Feb 4, 2012·Clinical and Experimental Pharmacology & Physiology·Markus Amann
Jun 7, 2014·The Journal of Experimental Biology·Renato PagliaraJ Maxwell Donelan
Jun 20, 2014·Journal of Neurophysiology·Dinant A KistemakerPaul L Gribble
May 4, 2015·Journal of Biomechanics·Jill E HubbuchJesse C Dean
Jul 11, 2015·Journal of Applied Physiology·Rachel W Jackson, Steven H Collins
Sep 15, 2015·Current Biology : CB·Jessica C SelingerJ Maxwell Donelan
Mar 19, 2016·Scientific Reports·Matthew B Yandell, Karl E Zelik

Citations

Sep 7, 2019·The Journal of Experimental Biology·Jessica C SelingerJ Maxwell Donelan
May 7, 2021·Frontiers in Bioengineering and Biotechnology·Benjamin A ShaferGregory S Sawicki
May 27, 2021·Royal Society Open Science·Cara Gonzalez WelkerSteven H Collins

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