PMID: 7520431May 1, 1994Paper

Is nitric oxide involved in cutaneous vasodilation during body heating in humans?

Journal of Applied Physiology
Niki M DietzMichael J Joyner

Abstract

The neurotransmitter responsible for neurogenic vasodilation in human skin during body heating is unknown. We sought to determine whether the vasodilating substance nitric oxide (NO) is involved in this phenomenon. Six subjects were heated for 50 min by use of a water-perfused suit while forearm blood flow (FBF) was measured with plethysmography and skin blood flow (SkBF) was measured by the laser-Doppler method in both arms. In one forearm, NG-monomethyl-L-arginine (L-NMMA), an NO synthase blocker, was infused into the brachial artery. Bolus doses of L-NMMA (< or = 4 mg/min) for 5 min were given to blunt NO-mediated vasodilator responses to acetylcholine (ACh, 64 micrograms/min). A continuous infusion of L-NMMA (< or = 1.0 mg/min) was used during body heating to maintain NO synthase blockade. In the forearm receiving L-NMMA, FBF was 1.8 +/- 0.3 ml.100 ml-1.min-1 before drug infusion and rose to 9.5 +/- 1.3 ml.100 ml-1.min-1 with ACh. After L-NMMA infusion, FBF was 1.3 +/- 0.2 ml.100 ml-1.min-1 and rose to 2.6 +/- 0.4 ml.100 ml-1.min-1 with ACh (both P < 0.05 vs. pre-L-NMMA). Similar changes in SkBF were seen with ACh and L-NMMA, confirming that the drugs reached cutaneous vessels. With body heating, oral temperature increased ...Continue Reading

Citations

Oct 1, 1996·Journal of Applied Physiology·K A EngelkeM J Joyner
Mar 15, 1997·Annals of the New York Academy of Sciences·P C MillsD J Marlin
Feb 14, 1998·Journal of Applied Physiology·M J Joyner, N M Dietz
Sep 8, 1998·Journal of Applied Physiology·D L KelloggJ M Johnson
Apr 8, 1999·Journal of Applied Physiology·D L KelloggD O'Donnell
Jan 10, 2009·Journal of Applied Physiology·Garrett WelchGary W Mack
Mar 30, 2017·Temperature : Multidisciplinary Biomedical Journal·Brett J Wong, Casey G Hollowed
Feb 5, 2000·Journal of Applied Physiology·S ShastryM J Joyner
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregg R McCordChristopher T Minson
Apr 1, 1997·Journal of Applied Physiology·P C MillsN C Smith
Jan 15, 2005·Journal of Applied Physiology·D L KelloggJ V Green
May 13, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D F CottrellG T Pearson
May 28, 2010·Menopause : the Journal of the North American Menopause Society·Kimberly A HubingCraig G Crandall
Apr 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·K A EngelkeM J Joyner
Jun 1, 1997·Journal of Applied Physiology·N M DietzM J Joyner
Sep 6, 2003·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Michael J Joyner, Michael E Tschakovsky
Oct 22, 2005·Journal of Applied Physiology·Kichang Lee, Gary W Mack
Aug 27, 2003·Journal of Physiological Anthropology and Applied Human Science·Kazuaki Yamashita, Yutaka Tochihara
Jan 23, 2009·Physiological Genomics·Rodrigo G DiasCarlos E Negrão
Jul 18, 2012·Hypertension·Maria Janieire Nazaré Nunes AlvesCarlos Eduardo Negrão
May 27, 2003·The Journal of Physiology·John R HalliwillNiki M Dietz

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