Is nitric oxide involved in the regulation of the rat testicular vasculature?

Biology of Reproduction
E LissbrantA Bergh

Abstract

Using immunohistochemistry, endothelial nitric oxide synthase (NOS), and neuronal NOS were localized in the endothelium of rat testicular arteries and in Leydig cells, respectively. NADPH-diaphorase activity, indicating NOS activity, however, was present only in endothelial cells. In order to examine the role of nitric oxide (NO) in the regulation of rat testicular vasculature, intact and hCG-pretreated (50-100 IU hCG given s.c. 6 h earlier) animals were given injections of the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), 10 mg/kg i.v.). In all rats this resulted in a major increase in blood pressure. In intact, unstimulated animals, testicular vascular resistance was unaffected, and testicular blood flow consequently increased. In hCG-treated animals, in contrast, vascular resistance increased in an hCG dose-related way. L-NAME treatment also increased the hCG-induced accumulation of polymorphonuclear leukocytes in testicular venules. Treatment with N(G)-nitro-D-arginine methyl ester (D-NAME, 10 mg/kg i.v.), an inactive isomer of L-NAME, had no effect on the testicular vasculature. The study suggests that NO plays only a limited role in the regulation of testicular blood flow under basal conditions. After hCG tre...Continue Reading

Citations

Oct 17, 2003·Biology of Reproduction·Stina Häggström RudolfssonAnders Bergh
Oct 3, 2003·Biology of Reproduction·Nikki P Y Lee, C Yan Cheng
Jun 1, 2012·Systems Biology in Reproductive Medicine·Erkan ErkanGulben Erdem Huq
Dec 8, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Neelima Dubey nee Pathak, Bechan Lal
Mar 21, 2007·Anatomia, histologia, embryologia·H C KimT Shin
Mar 10, 2006·International Journal of Andrology·E LissbrantA Bergh
Oct 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ben A WeissmanMatthew P Hardy

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