Is normal beta-hCG regression curve helpful in the diagnosis of persistent trophoblastic disease?

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
N BehtashA Mousavi

Abstract

The aim of this study was to evaluate the probable usefulness of normal beta-human chorionic gonadotropin (beta-hCG) regression curve in the diagnosis of persistent trophoblastic disease (PTD). A log-value regression curve was developed from the means and 95% confidence limits of serial weekly serum beta-hCG titers of 43 patients with uneventful complete hydatidiform moles and 14 patients, who were previously confirmed as PTD. All 14 PTD patients (100%) had abnormal values, beyond normal range, within 4 weeks. beta-hCG was in its upper values, compared to normal regression curve at 2.29 +/- 0.19 weeks. This was earlier than plateau or rise detection at 4.21 +/- 0.33 weeks (P < 0.001). Within 3 weeks of evacuation, 13 of 14 (92.86%) PTD patients' beta-hCG values exceeded the normal range, whereas only six of 14 (42%) showed a rise or plateau. Our finding indicates that the normal beta-hCG regression curve may be useful for quicker detection of PTD than the plateau or rise of level.

References

Jun 15, 1977·American Journal of Obstetrics and Gynecology·C P MorrowR M Nakamura
Feb 1, 1993·Current Opinion in Obstetrics & Gynecology·D B SmithE S Newlands
Apr 4, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E I Kohorn
Apr 10, 2003·Obstetrics and Gynecology·Colleen M FeltmateRoss S Berkowitz
May 16, 2003·American Journal of Obstetrics and Gynecology·Sarah A KhanlianLaurence A Cole

❮ Previous
Next ❯

Citations

Aug 19, 2007·Journal of Cancer Research and Clinical Oncology·Nadereh Behtash, Mojgan Karimi Zarchi
May 22, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·N E van TrommelUNKNOWN Dutch Working Party on Trophoblastic Tumors
May 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Charlotte LybolChris M G Thomas
Jun 21, 2011·Gynecologic Oncology·Mo'iad AlazzamJohn Tidy
Mar 31, 2007·Gynecologic Oncology·Mark R Schoeberl
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nienke E van TrommelChris M Thomas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BJOG : an International Journal of Obstetrics and Gynaecology
Narendra PisalBarry W Hancock
The Australian & New Zealand Journal of Obstetrics & Gynaecology
Sabien WielsmaMichael Quinn
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Nienke E van TrommelDutch Working Party on Trophoblastic Tumors
© 2021 Meta ULC. All rights reserved