Is obesity associated with gastropharyngeal reflux disease?

World Journal of Gastroenterology : WJG
Cheol Woong ChoiGeun Am Song

Abstract

To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD). We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dual-probe pH monitoring from July 2003 to December 2006. The association between body mass index (BMI) and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate analyses. A total of 769 patients (307 men and 462 women; mean age 50.7 years) were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obese patients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obese patients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI (OR, 1.9; 95 CI, 1.3-2.9), but overweight patients did not demonstrate increased risk of GERD (OR, 1.2; 95 CI, 0.8-1.7). Both obese patients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI (OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively). Obesity ...Continue Reading

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Citations

Nov 26, 2011·Journal of Translational Medicine·Shaheen E Lakhan, Annette Kirchgessner
Jan 18, 2013·World Journal of Gastroenterology : WJG·Chun-Yan NiuJin-Yan Luo
Dec 23, 2014·Gastroenterology Research and Practice·Huihui SunShuchang Xu
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Sabine Roman, John E Pandolfino
Aug 11, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Yu Kyung ChoUNKNOWN Korean Society of Neurogastroenterology and Motility
Jun 10, 2017·World Journal of Gastroenterology : WJG·Chao ZhangZhong-Gao Wang
Mar 3, 2009·Gastroentérologie Clinique Et Biologique·D BéchadeJ-P Algayres

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