Is obesity in psoriatic arthritis associated with a poorer therapeutic response and more adverse effects of treatment with an anchor drug?

Reumatología clinica
Eva Galíndez, Loreto Carmona

Abstract

To assess the association between obesity, control of inflammatory activity and increased adverse effects in psoriatic arthritis (PsA) with disease-modifying anti-inflammatory drugs (DMARD). A systematic literature review was performed using MEDLINE and EMBASE databases following the guidelines of the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) consensus statement. Studies were selected if they included patients with PsA, obesity was studied as a predictive factor, and the outcome was adverse effects, including efficacy failure. Quality was assessed using an ad hoc risk of bias tool. A qualitative analysis was carried out by type of study and study population, quality and specific results. We found 1043 articles, discarding most of them on the basis of title and abstract. Ten articles were studied in detail and finally excluded three. The majority concluded, with statistically significant results, that in patients with PsA and treated with TNFα inhibitors (TNFαi), obesity is associated with poorer chances of achieving and maintaining a minimal disease activity, higher treatment discontinuation rates, and lower skin response. Regarding conventional synthetic DMARD, a trend toward a moderate increase in transam...Continue Reading

References

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Citations

May 8, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ahmed Jasim TwayejMichael Maes
Mar 25, 2020·Scandinavian Journal of Psychology·Elisa Huéscar HernándezJuan Antonio Moreno-Murcia
Jul 3, 2019·Clinical Rheumatology·Luisa CostaRaffaele Scarpa
Mar 17, 2018·BioMed Research International·Marco FioreGiovanni Damiani
Jul 16, 2019·Medicine·Rubén QueiroEstefanía Pardo
Jul 20, 2021·Reumatología clinica·José Andrés Lorenzo MartínManuel Rubén Queiro Silva

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