Is older maternal age a risk factor for preterm birth and fetal growth restriction? A systematic review

Health Care for Women International
Christine V Newburn-Cook, Judee E Onyskiw


To determine if there was an association between advancing maternal age and adverse pregnancy outcomes (preterm delivery and small-for-gestational-age births), a systematic review was conducted based on a comprehensive search of the literature from 1985 to 2002. Ten studies met the following inclusion criteria: (1) assessed risk factors for preterm birth by subtype (i.e., idiopathic preterm labor, preterm premature rupture of membranes) and small-for-gestational-age (SGA) birth (fetal growth restriction); (2) used acceptable definitions of these outcomes; (3) were published between January 1985 and December 2002; (4) were restricted to studies that have considered preterm birth due to idiopathic preterm labor or premature rupture of membranes or both; (5) were restricted to singleton live births; (6) were conducted in a developed country; and (7) were published in English. The majority of the studies reviewed found that older maternal age was associated with preterm birth. There is insufficient evidence to determine if older maternal age is an independent and direct risk factor for preterm birth and SGA birth, or a risk marker that exerts its influence on gestational age or birth weight or both through its association with age-...Continue Reading


Aug 1, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M MilnerR F Harrison
Sep 1, 1992·American Journal of Epidemiology·M S KramerR H Usher
May 1, 1992·American Journal of Obstetrics and Gynecology·J M LangE Lieberman
Aug 19, 1992·JAMA : the Journal of the American Medical Association·S CnattingiusL Isotalo
Jan 1, 1991·Clinical Nurse Specialist CNS·C F Waltz, B M Sylvia
Jul 1, 1991·Paediatric and Perinatal Epidemiology·J L Kiely
Sep 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D S SeidmanJ G Schenker
Mar 8, 1990·The New England Journal of Medicine·G S BerkowitzR L Berkowitz
Jan 1, 1989·Health Care for Women International·P K Mansfield, W McCool
Dec 1, 1989·American Journal of Public Health·S J Ventura
Nov 1, 1986·Obstetrical & Gynecological Survey·J P Hansen
Sep 17, 1987·The New England Journal of Medicine·E LiebermanS C Schoenbaum
Jan 10, 1985·The New England Journal of Medicine·M C McCormick
Mar 1, 1985·American Journal of Epidemiology·Z A Stein
May 1, 1985·American Journal of Obstetrics and Gynecology·D S KirzR K Freeman
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·B WinistörferL Ozzello
May 1, 1995·Human Reproduction·J Lansac
Feb 1, 1995·Journal of Epidemiology and Community Health·C RodríguezJ L Gutiérrez-Fisac
Jun 1, 1995·American Journal of Obstetrics and Gynecology·R A Bobrowski, S F Bottoms
Jan 1, 1995·Obstetrics and Gynecology·M PrysakA Kisly
Jan 1, 1994·Health Affairs·C L Littell
Jun 1, 1993·American Journal of Obstetrics and Gynecology·V Edge, R K Laros
Mar 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P VercelliniA Cardinale
Apr 1, 1996·Journal of Clinical Epidemiology·B L HarlowD McNellis
Jun 1, 1996·Obstetrics and Gynecology·A BiancoR L Berkowitz
Jun 1, 1996·American Journal of Obstetrics and Gynecology·B M MercerJ Roberts
Sep 1, 1996·American Journal of Obstetrics and Gynecology·G A DildyS L Clark
May 16, 1998·Epidemiology·G S BerkowitzD A Savitz
Nov 13, 1998·The New England Journal of Medicine·K S JosephR Platt
Dec 5, 1998·Obstetrics and Gynecology·M DulitzkiD S Seidman
Jan 23, 1999·Obstetrics and Gynecology·W M GilbertB Danielsen
Nov 5, 1999·Preventive Medicine·H S ScholzE Petru
Dec 10, 1999·Pediatrics·B GuyerD M Strobino
Jun 1, 1997·Maternal and Child Health Journal·K E HeckJ L Kiely
Dec 2, 2000·Paediatric and Perinatal Epidemiology·K E PickettS Selvin
Jun 1, 2001·Paediatric and Perinatal Epidemiology·G M ShawJ M Thorp
Nov 6, 2001·Pediatrics·K S JosephUNKNOWN Fetal and Infant Heath Study Group of the Canadian Perinatal Surveillance System
Feb 22, 2002·Paediatric and Perinatal Epidemiology·Paola Astolfi, Laura A Zonta
Feb 1, 1993·Journal of Population Economics·M L BlackburnD Neumark
Nov 29, 2002·Pediatrics·Marian F MacDormanBernard Guyer

❮ Previous
Next ❯


Oct 18, 2011·Archives of Gynecology and Obstetrics·B O Olusanya, O A Solanke
Aug 7, 2013·Current Hypertension Reports·Alison L Kent, Tejasvi Chaudhari
Jul 4, 2009·Health Care for Women International·Safina Hassan McIntyreNestor N Demianczuk
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Sven Montan
May 17, 2011·BMC Public Health·Laura CaccianiGabriella Guasticchi
Aug 6, 2013·Applied Health Economics and Health Policy·Harminder GulianiJohn Serieux
Mar 29, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nathalie AugerErnest Lo
Apr 10, 2014·International Journal of Hygiene and Environmental Health·Michael S BloomEugen S Gurzau
Apr 30, 2010·Women's Health·Maximilian B Franz, Peter W Husslein
Jun 17, 2008·Journal of Women's Health·Ali DelpishehBernard J Brabin
Oct 13, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M J CantoF Ojeda
Dec 25, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A MousiolisA Antsaklis
Aug 6, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L-K BereczkyB Szabó
Jan 19, 2016·Birth·Cecilia Ekéus, Helena Lindgren
Sep 9, 2006·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Karen BenziesChristine Newburn-Cook
Nov 2, 2007·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Patricia Dunphy SupleeJoan Rosen Bloch
Sep 24, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T'sang-T'ang HsiehTai-Ho Hung
Jul 9, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ben Chong-Pun Chan, Terence Tsz-Hsi Lao
Jun 4, 2014·Australian and New Zealand Journal of Public Health·Deborah DonoghueJohn Beard
Sep 13, 2014·International Journal of Nursing Practice·Khitam MohammadDebra K Creedy
Jul 15, 2015·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Ronit LubetzkyDror Mandel
Jun 16, 2015·Fertility and Sterility·Barbara J StegmannDonna Santillan
Jun 1, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·C-H ChenH-C Lin
Aug 2, 2014·International nursing review·K MohammadJ Foster
Sep 17, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·J WangS Tong
Nov 27, 2015·The Journal of Pediatrics·Susanna LeivonenAndre Sourander
Dec 23, 2014·Health Care for Women International·M Mazharul Islam, Charles Saki Bakheit
Nov 13, 2013·Journal of Affective Disorders·Roshan ChudalAlan S Brown
Jun 9, 2012·The Journal of Pediatrics·Katja M LampiAndre Sourander
Nov 5, 2013·The Journal of Pediatrics·Päivi Polo-KantolaAndre Sourander
Jun 24, 2016·Biodemography and Social Biology·Saskia HinFinn Hedefalk
Mar 14, 2017·American Journal of Obstetrics and Gynecology·Amelia S McLennanAlexander M Friedman
Aug 25, 2016·Revista da Escola de Enfermagem da U S P·Laura Leismann de OliveiraAna Lucia de Lourenzi Bonilha
Mar 20, 2015·Scandinavian Journal of Public Health·Anne Britt Vika NilsenErica Schytt
Jan 4, 2020·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Yeonwoo KimCatherine Cubbin

❮ Previous
Next ❯

Methods Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Obstetricia Et Gynecologica Scandinavica
Hamisu M SalihuGreg R Alexander
Obstetrics and Gynecology
Bo JacobssonIan Milsom
Obstetrics and Gynecology
Jane Cleary-GoldmanFASTER Consortium
European Journal of Obstetrics, Gynecology, and Reproductive Biology
T'sang-T'ang HsiehTai-Ho Hung
© 2021 Meta ULC. All rights reserved