Is Ovarian Cancer Being Managed According to Clinical Guidelines? Evidence From a Population-Based Clinical Audit

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Simona SobreroPaolo Zola

Abstract

In the northwestern Italian region of Piedmont, current statistics on hospitalizations show that surgical treatment for ovarian cancer (OC) is taking place in many small hospitals, as opposed to a more centralized approach. A population-based clinical audit was promoted to investigate whether OC is being managed according to clinical guidelines, identify determinants of lack of adherence to guidelines, and evaluate the association between adherence to guidelines and survival. Residents diagnosed with OC in 2009 were identified in the regional hospital discharge records database. All hospitalizations within 2 years from diagnosis were reviewed. Patients were classified according to their initial pattern of care, defined as "with curative intent" (CIPC) if including debulking surgery aimed at maximal cytoreduction. Adherence to guidelines for surgery and chemotherapy and the effects of this adherence on OC survival were investigated with logistic regression and Cox models. The final study sample consisted of 344 patients with OC, 215 (62.5%) of whom received CIPC. Increasing age, comorbidities, and metastases were negatively associated with receiving CIPC. In the CIPC group, surgical treatment was adherent to guidelines in 35.2%,...Continue Reading

References

May 1, 1968·Journal of the American Geriatrics Society·B S LinnL Gurel
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rosemary D CressSharon L Campleman
Dec 8, 2004·Cancer Investigation·Robert F Ozols
Feb 2, 2006·Journal of the National Cancer Institute·Craig C EarleJoan L Warren
Jul 3, 2007·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists
Mar 4, 2008·Journal of Clinical Epidemiology·Ileana BaldiGiovannino Ciccone
Mar 13, 2008·Journal of the National Cancer Institute·Flora VernooijYolanda van der Graaf
May 24, 2008·International Journal of Cancer. Journal International Du Cancer·Ling YangElisabete Weiderpass
Jan 13, 2009·Gynecologic Oncology·Flora VernooijYolanda van der Graaf
Jan 29, 2010·Gynecologic Oncology·Cheryl MercadoClifford Y Ko
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Oct 12, 2010·Gynecologic Oncology·Giovanni D AlettiWilliam A Cliby
Aug 24, 2011·Obstetrics and Gynecology·Melissa M ThrallHeidi J Gray
Nov 10, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MorganUNKNOWN National Comprehensive Cancer Network
Feb 14, 2013·Gynecologic Oncology·S JordanUNKNOWN Ovarian Cancer Patterns of Care Study Group
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 4, 2013·Journal of Ovarian Research·Vincenzo Dario MandatoUNKNOWN Gynecological Oncology Network of Emilia Romagna Region
Aug 8, 2013·Obstetrics and Gynecology·Anne M van AltenaLeon F A G Massuger
Dec 10, 2013·The Lancet Oncology·Roberta De AngelisUNKNOWN EUROCARE-5 Working Group
Aug 29, 2014·The Medical Journal of Australia·Satyamurthy AnuradhaSusan J Jordan
Feb 25, 2015·Current Oncology Reports·Deepa Maheswari NarasimhuluDennis S Chi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Simona SobreroPaolo Zola
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Mette Calundann NoerClaus Høgdall
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Claes G TropéHalldis Oksefjell
© 2022 Meta ULC. All rights reserved