Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part II: an explorative causal inference approach

Human Reproduction
Sacha La Bastide-Van GemertEdwin R Van den Heuvel

Abstract

What causal relationships underlie the associations between ovarian stimulation, the IVF procedure, parental-, fertility- and child characteristics, and blood pressure (BP) and anthropometrics of 4-year-old IVF children? Causal models compatible with the data suggest the presence of positive direct effects of controlled ovarian hyperstimulation as applied in IVF (COH-IVF) on systolic blood pressure (SBP) percentiles and subscapular skinfold thickness. Increasing evidence suggests that IVF is associated with higher blood pressure and altered body fat distribution in offspring, but underlying mechanisms describing the causal relationships between the variables are largely unknown. In this assessor-blinded follow-up study, 194 children were assessed. The attrition rate until the 4-year-old assessment was 10%. We measured blood pressure and anthropometrics of 4-year-old singletons born following COH-IVF (n = 63), or born following modified natural cycle IVF (MNC-IVF, n = 52) or born to subfertile couples who conceived naturally (Sub-NC, n = 79). Primary outcome measures were the SBP and diastolic blood pressure (DBP) percentiles. Anthropometrics included triceps and subscapular skinfold thickness. Causal inference search algorithms...Continue Reading

References

Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Apr 15, 2004·Artificial Intelligence in Medicine·Silvia AcidJosé Luis Salcedo
Aug 17, 2004·Epidemiology·Miguel A HernánJames M Robins
Jul 1, 2005·American Journal of Epidemiology·M Maria GlymourJames M Robins
Nov 24, 2006·American Journal of Therapeutics·John Somberg
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Manon CeelenHenriette A Delemarre-van de Waal
Feb 21, 2008·The Journal of Clinical Endocrinology and Metabolism·Manon CeelenHenriette A Delemarre-van de Waal
Jul 18, 2008·Epidemiology·Tyler J VanderWeeleJames M Robins
Feb 23, 2010·Journal of Theoretical Biology·Babatunde A OgunnaikeJeremy S Edwards
Mar 23, 2010·The International Journal of Biostatistics·Judea Pearl
Jun 10, 2010·Acta Paediatrica·Olaf Dammann
Jul 28, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Scott Ramsey
Nov 15, 2011·Human Reproduction·Florence BelvaJean De Schepper
May 23, 2012·Human Reproduction·M Jongbloed-PereboomM Hadders-Algra
Nov 30, 2012·Developmental Medicine and Child Neurology·Steven M Day, Robert J Reynolds
Nov 1, 1993·Clinical Biomechanics·J D Bryant, S R Bollen
Sep 5, 2013·Developmental Medicine and Child Neurology·Sacha La Bastide-Van Gemert, Edwin van den Heuvel

❮ Previous
Next ❯

Citations

Jul 9, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Jiahui DingMingmin Zhang
Apr 19, 2017·Journal of Developmental Origins of Health and Disease·M Chen, L K Heilbronn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.