PMID: 9159340May 1, 1997Paper

Is OVX1 a suitable marker for endometrial cancer?

Gynecologic Oncology
E P BeckW Jaeger

Abstract

The single most common cause leading to the diagnosis of endometrial cancer is postmenopausal bleeding. Although most patients with early-stage disease (FIGO stage I and II) can be cured, prognosis worsens considerably with increasing stage. While serum CA 125 levels are elevated only in a significant proportion of patients with advanced disease, recently a new serum marker (OVX1) for the detection of early-stage endometrial cancer was reported. Serum OVX1 levels were measured using an OVX1 radioimmunoassay (RIA) or enzyme immunoassay (EIA) in 192 patients with endometrial cancer. CA 125 levels were measured in 112 patients using the CIS ELSA CA 125 kit. Apparently healthy females had mean serum OVX1 levels measured with the OVX1-EIA of 1.34 +/- 0.74 U/ml, while patients with endometriosis had mean OVX1 serum levels of 3.15 +/- 2.45 U/ml. The mean OVX1 serum level for endometrial cancer patients was 2.00 +/- 1.32 U/ml. These values were 2.76 +/- 1.62, 6.10 +/- 4.66, and 5.37 +/- 3.49, respectively, using the OVX1-RIA assay. Applying a cutoff value of 2.8 U/ml, serum OVX1-EIA levels in endometrial cancer patients were increased in 25 of 127 patients (19.7%) with stage I disease, 5 of 17 patients with stage II (29.4%), 5 of 22 pa...Continue Reading

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Citations

Jul 30, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S GinathI Avinoach
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W A A TjalmaD J Cruickshank
May 1, 2008·Expert Opinion on Medical Diagnostics·Faina LinkovAnna Lokshin
Aug 24, 1999·Seminars in Ultrasound, CT, and MR·P A Dubbins, B Subba
Sep 22, 2009·American Journal of Obstetrics and Gynecology·Gina Farias-EisnerRobin Farias-Eisner
Jun 3, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Faina LinkovEmanuela Taioli
Nov 1, 2011·Gynecologic Oncology·Eleftheria KalogeraSean C Dowdy
Jan 28, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Martina MontagnanaGiuseppe Lippi
Jul 4, 2006·Wiener klinische Wochenschrift·Iztok Takac, Borut Gorisek
Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Angiolo GadducciAndrea Riccardo Genazzani

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