Is oxidative stress related to cadmium accumulation in the Mollusc Crassostrea angulata?

Aquatic Toxicology
Dayanara Macías-MayorgaJulián Blasco

Abstract

The kinetics of cadmium (Cd) accumulation in the gills and digestive gland of Crassotrea angulata at three concentrations of cadmium (0.088 μM, 0.44 μM and 2.22 μM) was monitored for 28 days. The relationship between accumulation and toxicity was studied using metallothionein-like protein (MTLP) concentration and reduced glutathione levels (GSH) as biochemical endpoints. The activity of enzymes which form part of the antioxidant defense system, in particular glutathione reductase (GR), total glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), as enzymatic endpoints, was also assessed. A first order kinetic model demonstrated that the accumulation process does not take place linearly, as the Cd concentration in gills and digestive gland tended toward a stationary state. Metallothionein-like protein is clearly induced by Cd accumulation; however, at high Cd concentrations the detoxification mechanism of this protein is affected. High Cd concentrations (2.22 μM) lead to a decrease in GSH levels, and also inhibit antioxidant enzyme activities, demonstrating the adverse effect of this metal on the antioxidant balance system.

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Citations

Dec 15, 2015·The Science of the Total Environment·Xuan Liu, Wen-Xiong Wang
Oct 26, 2016·Environmental Toxicology and Chemistry·Xuan Liu, Wen-Xiong Wang
Jul 6, 2019·Environmental Science and Pollution Research International·Allison Mass FitzgeraldWilliam G Wallace
Nov 24, 2017·Environmental Science and Pollution Research International·Wenyu ZhaoYing Xu
Feb 10, 2021·Environmental Science and Pollution Research International·Sofia Bio, Bruno Nunes
Jan 2, 2021·International Journal of Environmental Research and Public Health·Chee Kong YapKhalid Awadh Al-Mutairi
Jul 9, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kaida XuPengfei Li

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