Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

International Journal of Chronic Obstructive Pulmonary Disease
Stephanie HobbinsRobert A Stockley

Abstract

COPD is recognized as having a series of comorbidities potentially related to common inflammatory processes. Periodontitis is one of the most common human inflammatory diseases and has previously been associated with COPD in numerous observational studies. As periodontitis and COPD are both chronic, progressive conditions characterized by neutrophilic inflammation with subsequent proteolytic destruction of connective tissue, it has been proposed that they share common pathophysiological processes. The mechanisms proposed to link COPD and periodontitis include mechanical aspiration of oral contents into the respiratory tree, overspill of locally produced inflammatory mediators into the systemic circulation or oral or lung-derived bacteremia activating an acute-phase response and also reactive oxygen species (ROS) and cytokine release by systemic neutrophils at distant sites. Studies of systemic neutrophils in COPD and chronic periodontitis describe altered cellular functions that would predispose to inflammation and tissue destruction both in the lung and in the mouth, again potentially connecting these conditions. However, COPD and periodontitis also share risk factors such as age, chronic tobacco smoke exposure, and social dep...Continue Reading

Citations

Nov 11, 2017·Frontiers in Immunology·Ljubomir VitkovMatthias Hannig
Oct 27, 2017·Postgraduate Medicine·Elsa Maria CardosoMaria Cristina Manzanares-Céspedes
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Aug 15, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Kayo YoshidaKazumi Ozaki

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