PMID: 7034019Nov 1, 1981Paper

Is PGI2 arrhythmogenic? Investigations on ouabain induced arrhythmias in cats

Prostaglandins and Medicine
H J Mest, W Förster

Abstract

The present study investigated the effect of PGI2 on ouabain induced arrhythmias in cats. PGI2 was infused at a dose of 1.0, 2.0 and 5.0 microgram/kg . min. PGI2 in a dose of 1.0 microgram/kg . min was without any antiarrhythmic effect. Infusions of 2.0 and 5.0 microgram/kg . min PGI2 in 3 of 10 and 7 of 10 animals, respectively, converted the ouabain induced arrhythmias into a sinus rhythm. The duration of the antiarrhythmic effect after infusion of 2.0 microgram/kg . min lasted about 21 min, whereas the higher dose (5.0 microgram/kg . min) had a shorter effect (about 2 min). Under these conditions and doses the systolic blood pressure decreased between 35% and 39% and the diastolic blood pressure was reduced by about 50%. Thus PGI2 showed when used in the given dose range, an antiarrhythmic effect on ouabain induced arrhythmias in cats. The importance of dosage, methods and species is here discussed.

References

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Citations

Nov 1, 1988·Journal of Pharmacological Methods·T S RaoS C Manchanda
Jul 1, 1987·Prostaglandins, Leukotrienes, and Medicine·J BeitzH J Mest
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H J MestC Giessler
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A BeitzH J Mest
Sep 1, 1982·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W E Lönnig
May 1, 1985·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W Gottschalk
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Vapaatalo

Related Concepts

Cardiac Arrhythmia
Diastolic Blood Pressure
Felis catus
Dose-Response Relationship, Drug
Pulse Rate
Ouabain
Prostaglandins
Flolan

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