Is plasma serine a marker for psychosis?

Biological Psychiatry
G F CarlB K Young

Abstract

There is some disagreement in the literature concerning the use of plasma serine concentrations as a biological marker for psychoses including schizophrenia. The groups studying this phenomenon have used different methodologies, including gas chromatography and classical amino acid analysis. In the present study, using high pressure liquid chromatography to analyze plasma amino acids from schizophrenics and controls, we found no difference in plasma serine concentrations. None of the plasma amino acid concentrations that were measured differed significantly between schizophrenics and controls but the basic amino acids tended toward higher concentrations in schizophrenics.

References

Apr 1, 1990·Psychiatry Research·F MacciardiE Smeraldi
Jun 1, 1986·Psychiatry Research·R Waziri, J Mott
Sep 1, 1985·Journal of Affective Disorders·R WaziriJ Wilcox
Jun 1, 1985·Psychiatry Research·T L Perry, S Hansen
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott
Jul 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·R WaziriA D Sherman

Citations

Jun 1, 2003·Acta Neuropsychiatrica·F M M A van der HeijdenS Tuinier
Aug 16, 2012·Translational Psychiatry·Y HeD Rujescu
Jan 26, 2010·Psychiatry Research·Jaromir HonsJan Libiger
Apr 17, 2012·Journal of Psychiatric Research·Jaromir HonsJan Libiger
May 5, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua ChiappelliL Elliot Hong
Mar 17, 2004·Current Opinion in Neurology·Tom J de Koning, Leo W J Klomp
Jan 5, 2010·Psychiatry Investigation·Vincenzo De LucaMarcellino Monda

Related Concepts

High Pressure Liquid Chromatography Procedure
Schizophrenia
Serine
Viral Markers

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