To determine whether endogenous PAF contributes to the pathogenesis of endotoxin shock, CV-3988, a specific PAF antagonist, was injected i.v. to rats before, simultaneously with or after endotoxin. CV-3988 (5 mg/kg i.v.) injected 5 min before the endotoxin completely inhibited endotoxin (15 mg/kg i.v.)-induced hypotension, and CV-3988 (0.05-1 mg/kg i.v.) injected 7-10 min after the endotoxin rapidly reversed endotoxin-induced hypotension. A combination of CV-3988 (10 mg/kg) with endotoxin (5 mg/kg) administered i.v. improved the survival rate for 20 h or more. CV-3988 (0.05-1 mg/kg i.v.) rapidly reversed the PAF (1 microgram/kg i.v.)-induced hypotension. These findings strongly suggest that endogenous PAF may play a pivotal role in the pathogenesis of endotoxin shock.
Unilateral Shwartzman reaction: cortical necrosis in one kidney following in vivo perfusion with endotoxin
Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues
Change in membrane lipid fluidity induced by phospholipase A activation: a mechanism of endotoxic shock
Effect of 1-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine inhibitor on the reduction of one-kidney, one clip hypertension after unclipping in the rat
Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets
Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives
An experimental study of gastric mucosal blood flow in endotoxemia of the rat, with special reference to the vagus nerve and EDRF
Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone
Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury
Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988
Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis
Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats
Attenuation of burn-induced changes in hemodynamics and glucose metabolism by the PAF antagonist SRI 63-675
Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice
Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen
Protective effect of DS-4574, a peptidoleukotriene receptor antagonist, against endotoxin-induced intestinal injury in rats
Effect of FR128998, a novel PAF receptor antagonist, on endotoxin-induced disseminated intravascular coagulation
Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam
Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants
Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig
The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed
Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis
Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat
Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor
Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist
Biological properties of the antagonist SRI 63-441 in the PAF and endotoxin models of hypotension in the rat and dog
Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor
Platelet-activating factor and hyperacute rejection. The effect of a platelet-activating factor antagonist, SRI 63-441, on rejection of xenografts and allografts in sensitized hosts
The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion
Role of platelet-activating-factor (PAF) on cellular responses after stimulation with leptospire lipopolysaccharide
Antagonism of endotoxin-induced disruption of equine gastrointestinal motility with the platelet-activating factor antagonist WEB 2086
Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells
Evidence for the involvement of a plasma kallikrein-kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats
Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice
Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock
Long-lasting inhibitory activity of the hetrazepinic BN 50730 on exudation and cellular alterations evoked by PAF and LPS
Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis
Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli
Comparison of heartworm extract-induced shock and endotoxin-induced shock in dogs by determination of serum tumor necrosis factor concentrations
Detection of platelet-activating factor in exudates of rats with phorbol myristate acetate-induced pleurisy
Protective effect of a specific platelet-activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats
Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs
Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils
Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages
Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man
Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist
The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig
Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists
Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin
Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats
Protective effects of a specific platelet activating factor (PAF) antagonist, WEB 2086, in traumatic shock
Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L
Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells
Platelet-activating factor receptor-dependent activation of the muscarinic K+ current in bullfrog atrial myocytes
Development of an in vivo bioassay method for allergy-preventive substances using hen-egg white lysozyme (HEL)-induced blood flow decrease
A model for the investigation of factors influencing haemorrhagic necrosis mediated by tumour necrosis factor in tissue sites primed with mycobacterial antigen preparations
Augmented production of platelet-activating factor in human polymorphonuclear leukocytes by ketone bodies
Improvement of survival from hemorrhagic shock by enterectomy in rats: finding to implicate the role of the gut for irreversibility of hemorrhagic shock
PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis
Effects of platelet-activating factor on beta- and H2-receptor-mediated increase of myocardial contractile force in isolated perfused guinea pig hearts
Development of a high-performance liquid chromatographic-mass spectrometric technique, with an ionspray interface, for the determination of platelet-activating factor (PAF) and lyso-PAF in biological samples
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