Is Platinum Present in Blood and Urine from Treatment Givers during Hyperthermic Intraperitoneal Chemotherapy?

Journal of Oncology
Sara Näslund AndréassonH Mahteme

Abstract

Background. In selected patients with peritoneal carcinomatosis (PC) originating from colorectal cancer (CRC) the high dosage of oxaliplatin (460 mg/m(2)) is recommended for hyperthermic intraperitoneal chemotherapy (HIPEC), which may be a health risk to those administering the drug. The aim of this study was to determine the risk of platinum (Pt) exposure for the two main people handling and administering the cytotoxic agent during HIPEC. Methods. Samples of blood and urine were collected from one male surgeon and one female perfusionist during oxaliplatin-based HIPEC treatment with open abdomen coliseum technique on six consecutive patients with PC from CRC. Results. All blood samples analysed were below the detection limit of <0.05 nmol/L Pt, and the urine samples were all below the detection limit of <0.03 nmol/L Pt. Conclusions. There appears to be little or no risk of Pt exposure during HIPEC when the recommended protective garment is used and the safety considerations are followed.

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Citations

Apr 15, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A CaneparoM De Simone
Aug 13, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G FerronL Villeneuve
Mar 19, 2015·International Journal of Surgical Oncology·E HalkiaJ Spiliotis
Oct 2, 2012·Surgical Oncology Clinics of North America·Santiago González-MorenoGloria Ortega-Pérez
May 5, 2016·International Archives of Occupational and Environmental Health·K-E SchenkD Nowak
Mar 7, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Marie PalaminiJean-François Bussières
Dec 1, 2016·Pleura and Peritoneum·Martin GraversenMichael B Mortensen
Apr 12, 2016·Indian Journal of Surgical Oncology·Aditi BhattK S Gopinath

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