PMID: 9192960May 1, 1997Paper

Is post-operative radiation for renal cell carcinoma justified?

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
I ArefD Salhani

Abstract

To identify the pattern of failure in patients with resected renal cell carcinoma (RCC). The records of 116 patients with unilateral, non-hematogenous metastatic RCC who were treated with definitive surgery and referred to the Ottawa Regional Cancer Centre between 1977 and 1988 were reviewed. Distribution by stage included T1 (3 patients), T2 (42 patients) and T3 (71 patients). The median follow-up was 44 months, with a range of 4-267 months. Local regional failure (LRF) developed in 8 patients. Nine patients developed local or regional recurrence, plus distant failure. Fifty-eight patients had distant metastases (DM) only. The 7-year actuarial rate for LRF and DM were 12%, and 67%, respectively. The overall 7-year actuarial survival rate was 35%, and cause-specific survival was 42%. LRF alone is rare following nephrectomy. DM is the main pattern of failure. This data does not support the role of adjuvant radiation therapy in this disease.

References

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Feb 1, 1969·British Journal of Urology·W B PeelingB G Shepheard

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Citations

Jul 1, 2005·World Journal of Urology·Shomik SenguptaHorst Zincke
Dec 17, 2008·La Radiologia medica·M TroianoS Parisi
Feb 9, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A TunioM Rafi
Apr 11, 2012·The Urologic Clinics of North America·Patrick A Kenney, Christopher G Wood
Oct 14, 2006·Current Opinion in Urology·D Y Chan, F F Marshall
Jul 25, 2006·Clinical Genitourinary Cancer·Navneet S MajhailRonald M Bukowski

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