Is pre-operative radiotherapy necessary in T-T rectal cancer with TME?

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
G MackayP J O'Dwyer

Abstract

The indications for pre-operative radiotherapy in rectal cancer are still unclear with the exception of T4 tumours. The aim of this study was to assess local and overall recurrence in patients with T1-T3 rectal cancers undergoing total mesorectal excision (TME). Prospective data was collected from 150 patients with rectal cancer treated in one surgical centre between July 1997 and July 2002. One hundred and twenty-nine primary resections were carried of which 102 were with curative intent. Seventy-nine patients with T1-T3 tumours were included in the analysis. Nine had local resections and 70 underwent TME; 19 of the 70 patients were node positive and 51 were node negative. At a median follow-up of 37 months (range 19-79 months) there were 3 (4.3%) isolated local recurrences. One node positive patient developed isolated local recurrence compared with 2 node negative patients. The node positive patient died from a myocardial infarction while the two node negative patients died as a consequence of local recurrence. Three (4.3%) of 70 patients developed systemic relapse all of whom were node positive. The cancer specific mortality rate over the same follow-up period was 3/19 for node positive patients and 2/51 for node negative pa...Continue Reading

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Citations

Jul 3, 2008·International Journal of Colorectal Disease·Shin FujitaYoshihiro Moriya
Jul 18, 2008·International Journal of Colorectal Disease·Joachim StrassburgPaul Hermanek
Dec 21, 2006·Diseases of the Colon and Rectum·Morten T EriksenUNKNOWN Norwegian Rectal Cancer Group
Dec 8, 2006·The New England Journal of Medicine·Gavin C Harewood
Oct 26, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S Anwar
Oct 18, 2011·Radiología·R García FigueirasA Gómez Caamaño
Jan 23, 2009·Patient Education and Counseling·James D HarrisonTim Whelan
Aug 28, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·I Craven, D Sebag-Montefiore
Sep 25, 2008·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·H H WasmuthO Røkke
Jan 2, 2008·Gastroentérologie Clinique Et Biologique·Pascal FrileuxAude Brams

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