Is prednisolone as good as flutamide in hormone refractory metastatic carcinoma of the prostate?

The Journal of Urology
S N DattaP N Matthews

Abstract

There are no generally accepted rules for the second line treatment of prostate cancer and few prospective studies have attempted to compare 2 therapeutic strategies with different modes of action. We describe a prospective, randomized study of 40 patients comparing the second line response of flutamide to prednisolone in patients with known hormone refractory stage M1 prostate cancer. The median survival of patients receiving either treatment was 32.9 weeks, with no difference between the 2 groups. In terms of biological response 11 of 20 patients (55%) receiving prednisolone and 10 of 20 (50%) receiving flutamide exhibited prostate specific antigen (PSA) suppression. Average minimum PSA was 54 and 52% of the initial PSA in patients receiving prednisolone and flutamide, respectively. There was no difference between the 2 treatment groups in terms of long-term survival, although 35% of all patients survived beyond 1 year and 3 survived beyond 2 years. More patients taking prednisolone described better pain relief, although both medications were well tolerated and there was no difference in terms of performance status or analgesic requirements.

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Citations

Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Ali Reza Mohajjel Nayebi, Hassan Rezazadeh
Jun 8, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·T SaikaUNKNOWN Okayama Urological Cancer Collaborating Group
Mar 25, 2006·Future Oncology·D C Gilbert, C Parker
Dec 2, 2004·Annales D'urologie·G FournierO Cussenot
Apr 25, 2015·The Cochrane Database of Systematic Reviews·Alison HaywoodJanet R Hardy
Oct 21, 2006·The Cochrane Database of Systematic Reviews·Mike ShelleyMalcolm D Mason

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