PMID: 11336321May 5, 2001Paper

Is preventive resection of the extrahepatic bile duct necessary in cases of pancreaticobiliary maljunction without dilatation of the bile duct?

Japanese Journal of Clinical Oncology
T AokiY Koyanagi

Abstract

No consensus has been reached on whether preventive resection of the extrahepatic bile duct is necessary in cases of pancreaticobiliary maljunction (PBM) without dilatation of the extrahepatic bile duct (undilated type). Sixty-eight patients with PBM underwent corrective surgery and several clinical characteristics and pathological findings including K-ras point mutation were evaluated. Unlike dilated bile duct, none of the patients with undilated type duct had clinical symptoms in early childhood. In patients with either cystic or spindle type duct, amylase levels in the bile duct were >10(4) U/l, whereas those in patients with undilated type duct were <10(4) U/l. Postoperative scintigraphy of the biliary system of undilated type revealed no evidence of cholestasis. After surgery, eight patients with undilated type duct, in whom the bile duct had been preserved, had no further clinical symptoms and no evidence of malignancy. Bile duct tissue specimens revealed no hyperplasia, dysplasia or cancerous lesions and they had no K-ras mutation in undilated type. The results showed that there was little bile stasis, injury to the mucosa was mild and less genetic changes could be seen in patients with undilated type duct. Therefore, in...Continue Reading

Citations

Dec 11, 2003·Journal of Pediatric Surgery·Akihiro ShimotakaharaTakeshi Miyano
Nov 27, 2008·World Journal of Gastroenterology : WJG·Terumi KamisawaKouji Tsuruta
Jul 19, 2012·World Journal of Gastroenterology : WJG·Kensuke TakumaYoshinori Igarashi
Mar 13, 2012·World Journal of Gastroenterology : WJG·Suk Keu YeomJong Jin Hyun
Jun 6, 2013·Journal of Gastroenterology·Jun HoraguchiUNKNOWN committee of Diagnostic Criteria of The Japanese Study Group on Pancreaticobiliary Maljunction
Apr 16, 2010·Journal of Hepato-biliary-pancreatic Sciences·Terumi KamisawaUNKNOWN Committee of Diagnostic Criteria of The Japanese Study Group on Pancreaticobiliary
Jan 12, 2019·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·I HyvärinenM P Pakarinen

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