Is Previous Transanal Endoscopic Microsurgery for Early Rectal Cancer a Risk Factor of Worse Outcome following Salvage Surgery A Case-Matched Analysis

Visceral Medicine
Audrius DulskasNarimantas E Samalavičius

Abstract

Transanal endoscopic microsurgery (TEM) is a minimally invasive procedure which allows local excision of early-stage rectal cancer and can be used as an alternative treatment to radical surgery. Patients can undergo salvage total mesorectal excision (sTME) following TEM after finding of unfavourable histological features. This study aimed to compare results and possible complications of sTME following TEM and primary TME (pTME) procedures. Between 2010 and 2017, early sTME was performed in 9 patients at the National Cancer Institute in Vilnius, Lithuania. These patients were compared with 18 patients who underwent pTME, matched according to gender, age, cancer stage, and operative procedure. Data were obtained from the patients' charts and reviewed prospectively. We recorded the demographics, tumour specifications, treatment, operation time, postoperative results complications, and oncological outcome. Fisher's exact test and student's T test was used to compare both groups. A total of 130 patients underwent TEM at our institution during the study period, of which 9 (6.92%) had to undergo sTME. The average age of the patients was 62.7 ± 7.07 years; 44.4% of the patients were male and 55.6% female. The average tumour size in the...Continue Reading

References

Jan 1, 1992·American Journal of Surgery·G BuessH D Becker
Aug 26, 1998·Archives of Surgery·R J HealdJ K MacFarlane
Feb 23, 2002·The American Journal of Surgical Pathology·Iris D NagtegaalUNKNOWN Cooperative Clinical Investigators
Jul 17, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T NakagoeT Tsuji
Dec 29, 2004·Diseases of the Colon and Rectum·D GopaulPhilip H Gordon
Feb 16, 2005·Diseases of the Colon and Rectum·Philippa F MiddletonGuy J Maddern
Mar 5, 2005·Diseases of the Colon and Rectum·Dieter HahnloserSanthat Nivatvongs
Feb 8, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M GuerrieriE Lezoche
Jun 16, 2007·International Journal of Colorectal Disease·Byung Soh MinSeung Kook Sohn
Jun 3, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E J R De GraafC J H van de Velde
Dec 17, 2009·Diseases of the Colon and Rectum·Ben M TsaiAnders Mellgren
Mar 30, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E J R de GraafW C J Hop
Oct 21, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S BülowUNKNOWN Danish Colorectal Cancer Group
Mar 19, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R HompesUNKNOWN Association of Coloproctology of Great Britain and Ireland Transanal Endoscopic Microsurgery Collaboration
Jul 11, 2014·World Journal of Surgical Oncology·Gongping SunGaofeng Liang
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Jan 13, 2016·Techniques in Coloproctology·N E SamalaviciusG Smailyte
Mar 16, 2017·Annals of Coloproctology·Audrius DulskasNarimantas E Samalavicius
Nov 4, 2017·ANZ Journal of Surgery·Narimantas E SamalaviciusAlfredas Kilius
Jul 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

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